411242-07-4

Upstream product

• 81677-37-4 (E)-tert-butyl(pent-2-en-4-yn-1-yloxy)diphenylsilane 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 35042-52-5 (E)-2-penten-4-yn-1-ol 

Downstream Products

• 381665-45-8 (6R)-6-{(1E,3R,4R,6R,7Z,9Z,11E)-6-{[tert-butyl(dimethyl)silyl]oxy}-13-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxy-3-methyl-3-[(triethylsilyl)oxy]trideca-1,7,9,11-tetraen-1-yl}-5,6-dihydro-2H-pyran-2-one 
• 411242-10-9 1-[1(R)-(tert-butyldimethylsilanyloxy)-1(R)-methyl-3-(6-oxo-3,6-dihydro-2H-pyran-2(R)-yl)allyl]-3(R),10-bis(tert-butyldiphenylsilanyloxy)-deca-4(Z),6(Z),8(E)-trienyl bis[2-(trimethylsilanyl)ethyl] phosphate 
• 411242-09-6 6(R)-[3(R)-(tert-butyldimethylsilanyloxy)-6(R),13-bis-(tert-butyldiphenylsilanyloxy)-4(R)-hydroxy-3(R)-methyltrideca-1(E),7(Z),9(Z),11(E)-tetraenyl]-5,6-dihydro-pyran-2-one 
• 411242-08-5 6(R)-[6(R),13-bis(tert-butyldiphenylsilanyloxy)-3(R),4(R)-dihydroxy-3(R)-methyltrideca-1(E),7(Z),9(Z),11(E)-tetraenyl]-5,6-dihydropyran-2-one 

Relevant academic research and scientific papers

Convergent synthesis of fostriecin via selective alkene couplings and regioselective asymmetric dihydroxylation

"Chemical Equation Presented" A highly convergent synthesis of fostriecin Is described, featuring sequential palladium-catalyzed Negishi cross couplings to form the C7-C8 bond and C8-methyl bond, followed by late-stage regio- and stereoselective dihydroxy

Highly convergent, stereospecific synthesis of 11-cis-retinoids by metal-catalyzed cross-coupling reactions of (Z)-1-alkenylmetals

(Chemical Equation Presented) A stereospecific synthesis of 11-cis-retinoids has as its key step the hitherto unexplored palladium-catalyzed cross-coupling of trans-tnenyl electrophiles and (1Z,3E)-penta-1,3-dienyl boronates (a Suzuki-Miyaura reaction) or

Asymmetric total synthesis of (+)-fostriecin

(equation presented) The title compound, a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multiconvergent asymmetric synthesis. Key transformations include a ring forming olefin metathesis leading to the α,β-unsat