41143-22-0Relevant academic research and scientific papers
Alternative synthetic approaches to rac-progesterone by way of the classic Johnson cationic polycyclization strategy
Slegeris, Rimantas,Dudley, Gregory B.
, p. 3666 - 3672 (2016)
Three alternative synthetic entries into Johnson's classic synthesis of rac-progesterone are presented in this manuscript. ent-Progesterone, the non-natural enantiomer of progesterone, has recently been identified as a potential alternative to progesterone for investigations into possible prevention and treatment of traumatic brain injury (TBI). Difficulties in accessing ent-progesterone in large quantities prevent it from being studied more thoroughly. Strategies for producing synthetic rac-progesterone are described and discussed herein.
