41145-61-3Relevant academic research and scientific papers
5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS
-
, (2014/01/07)
The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
Transformation of the bromine end group into thiol in (Meth)acrylic polymers synthesized by atom transfer radical polymerization
Liras,Garcia,Quijada-Garrido,Paris
experimental part, p. 1335 - 1339 (2011/10/05)
The halogen end group of polymers prepared via atom transfer radical polymerization (ATRP) can be converted into other functional groups by different chemical modifications. Herein, a new method to modify the bromine end group into a thiol functionality in (meth)acrylic polymers synthesized by ATRP is reported for the first time. Thus, the bromine end group of several poly(methyl methacrylate)s was successfully converted into a thioacetate and then in a mercapto group by a controlled hydrolysis. This end-functionalization was confirmed introducing in situ a fluorescent group by thiol-ene "click" reaction with a synthetic alquene tethered to a 4,4-difluoro-4-bora-3a,4a- diaza-s-indacene (BODIPY) fragment. In addition, two model reactions in which bromide ATRP initiators were transformed into new thiol-functionalized molecules proved that this methodology can be applied to either methacrylic or acrylic polymers synthesized by ATRP.
