4115-19-9

Usage

Explanation

The compound is composed of 17 carbon atoms, 14 hydrogen atoms, 2 nitrogen atoms, and 1 sulfur atom.

Explanation

It belongs to the thiadiazole family of chemical compounds, which are known for their diverse biological activities.

Explanation

Laboratory tests have shown that 1,2,4-Thiadiazole, 3,5-bis(phenylmethyl)- exhibits antibacterial and anticancer properties, making it a potential candidate for further research in medicinal chemistry.

Explanation

Due to its biological activities, 1,2,4-Thiadiazole, 3,5-bis(phenylmethyl)has potential applications in the field of medicinal chemistry, particularly in the development of new drugs.

Explanation

1,2,4-Thiadiazole, 3,5-bis(phenylmethyl)- has been researched for its potential use as a building block in the synthesis of other organic compounds, which could lead to the development of new materials and pharmaceuticals.

Explanation

The compound's diverse properties and potential applications make it a versatile compound with promising uses in a range of scientific and medical fields.

Family

Thiadiazole

Biological Activities

Antibacterial and anticancer properties

Potential Applications

Medicinal chemistry

Research Area

Building block in organic synthesis

Versatility

Promising applications in various scientific and medical fields

Upstream product

• 645-54-5 2-phenylthioacetamide 
• 76254-71-2 phenyl-thioacetic acid amide-S-oxide 
• 140-29-4 phenylacetonitrile 

Relevant academic research and scientific papers

An Expeditious Ultrasound-Initiated Green Synthesis of 1,2,4-Thiadiazoles in Water

[Figure not available: see fulltext.] A convenient, environmentally benign, metal- and catalyst-free protocol has been developed for the conversion of thioamides to the corresponding 1,2,4-thiadiazole derivatives with chloranil under ultrasound irradiation in water at room temperature. This paper describes a general procedure for the synthesis of different 1,2,4-thiadiazoles in excellent yield in short reaction time via sonochemistry.

Highly efficient synthesis of 1,2,4-thiadiazoles from thioamides utilizing tetra(n-butyl)ammonium peroxydisulfate

A new synthetic approach to 1,2,4-thiadiazoles using tetra(n-butyl)ammonium peroxydisulfate via oxidative dimerization of thioamides is described. This new oxidative protocol is simple, highly efficient, and allows the practical synthesis of 1,2,4-thiadiazoles from various primary thioamides in good to excellent yields.

Novel method for electrochemically synthesizing 1, 2, 4 - thiadiazole compounds

The invention discloses a novel method for electrochemically synthesizing a 1,2,4-thiadiazole compound. Specifically, the novel method comprises the following steps: adding 0.5mmol of thioamide, 0.025mmol of ammonium iodide, 3mL of methanol and 3mL of ace

tert-Butyl nitrite induced radical dimerization of primary thioamides and selenoamides at room temperature

A simple and efficient method for the dimerization of primary thioamides into 1,2,4-thiadiazoles using tert-butyl nitrite is described. The optimized condition was also found to be suitable for the dimerization of benzoselenoamides into 1,2,4-selenadiazoles. All the reactions proceed smoothly at room temperature and gave the desired products in excellent yields in a short span of time.

Electrochemical Synthesis of 3,5-Disubstituted-1,2,4-thiadiazoles through NH4I-Mediated Dimerization of Thioamides

A electrochemical method for the synthesis of 3,5-disubstituted-1,2,4-thiadiazoles through NH4I-mediated dimerization of thioamides is reported. Using the inexpensive NH4I as electrolyte and catalyst, this electrosynthesis approach requires no oxidizing agents and enables the convenient production of diverse 1,2,4-thiadiazoles products. The approach is an example of S?N bond construction through the electrochemical method. (Figure presented.).

Synthesis of 1,2,4-thiadiazoles by oxidative dimerization of carbothioamides by using oxone

1,2,4-Thiadiazoles were efficiently synthesized in good yields through the oxidative dimerization of carbothioamides by using Oxone as a readily available, inexpensive, and environmentally safe oxidant. A similar reaction of phenylselenoamide led to the corresponding 1,2,4-phenylselenadiazole in high yield. Copyright

IBX/TEAB-mediated oxidative dimerization of thioamides: synthesis of 3,5-disubstituted 1,2,4-thiadiazoles

Thioamides undergo oxidative dimerization on treatment with hypervalent iodine(V)-containing reagents, particularly o-iodoxybenzoic acid (IBX), in the presence of tetraethylammonium bromide (TEAB) to generate 3,5-disubstituted 1,2,4-thiadiazoles in excellent yield.

Convenient Preparations of 3,5-Disubstituted 1,2,4-Thiadiazoles by Oxidative Dimerization of Thioamides

3,5-Disubstituted 1,2,4-thiadiazoles 2 were prepared by reaction of thioamides 1 with DMSO in the presence of such an electrophilic reagent as 1-methyl-2-chloropyridinium iodide, benzoyl chloride, acetyl chloride, hydrochloric acid, or trimethylsilyl chloride in organic solvents at room temperature in high yields.Thiadiazoles 2 were also obtained by reaction of 1 with NBS at room temperature in high yields.Thioamide S-oxides reacted with electrophilic reagents at room temperature to give the corresponding thiadiazoles 2 in high yields.