4117-31-1

Basic information

• Product Name: ETHYL SERINATE
• Synonyms: (S)-2-Amino-3-hydroxypropanoic acid ethyl ester;(S)-2-Amino-3-hydroxypropionic acid ethyl ester;L-Serine ethyl ester
• CAS NO: 4117-31-1
• Molecular Formula: C₅H₁₁NO₃
• Molecular Weight: 133.15
• Mol File: 4117-31-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 247.9±20.0 °C(Predicted)
• Appearance: /
• Density: 1.146±0.06 g/cm3(Predicted)
• PKA: 12.01±0.10(Predicted)
• CAS DataBase Reference: ETHYL SERINATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL SERINATE(4117-31-1)
• EPA Substance Registry System: ETHYL SERINATE(4117-31-1)

Safety Data

• Hazardous Substances Data: 4117-31-1(Hazardous Substances Data)

Upstream product

• 56-45-1 L-serin 
• 122-51-0 orthoformic acid triethyl ester 
• 26348-61-8 L-serine ethyl ester hydrochloride 
• 64-17-5 ethanol 

Downstream Products

• 78979-39-2 (S)-2-(4-Chloro-phenyl)-oxazolidine-4-carboxylic acid ethyl ester 
• 78979-37-0 (S)-2-Phenyl-oxazolidine-4-carboxylic acid ethyl ester 
• 78979-38-1 (S)-2-(4-Methoxy-phenyl)-oxazolidine-4-carboxylic acid ethyl ester 
• 77250-61-4 ethyl (S)-2-phenyl-4,5-dihydrooxazole-4-carboxylate 
• 61999-29-9 2-Methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid ethyl ester 
• 1346756-66-8 N-Cbz-L-Phe-L-Ser-OEt 
• 1414546-12-5 C₂₄H₁₉N₃O₄ 
• 1414545-89-3 C₁₉H₁₄N₂O₅ 
• 1414545-57-5 C₁₉H₁₄N₂O₄S 
• 1414547-50-4 (2S)-ethyl 3-hydroxy-2-[5-(1-methyl-1H-indol-3-yl)-2-phenyloxazole-4-carboxamido]propanoate 
• 1414547-46-8 (2S)-ethyl 2-[5-(furan-2-yl)-2-phenyloxazole-4-carboxamido]-3-hydroxypropanoate 
• 1414547-42-4 (2S)-ethyl 3-hydroxy-2-[2-phenyl-5-(thiophen-2-yl)oxazole-4-carboxamido]propanoate 
• 1414547-48-0 C₂₅H₂₇N₃O₅S 

Relevant articles and documents

Stereoretentive N-Arylation of Amino Acid Esters with Cyclohexanones Utilizing a Continuous-Flow System

The N-arylation of chiral amino acid esters with minimal racemization is a challenging transformation because of the sensitivity of the α-stereocenter. A versatile synthetic method was developed to prepare N-arylated amino acid esters using cyclohexanones as aryl sources under continuous-flow conditions. The designed flow system, which consists of a coil reactor and a packed-bed reactor containing a Pd(OH)2/C catalyst, efficiently afforded the desired N-arylated amino acids without significant racemization, accompanied by only small amounts of easily removable co-products (i. e., H2O and alkanes). The efficiency and robustness of this method allowed for the continuous synthesis of the desired product in very high yield and enantiopurity with high space-time yield (74.1 g L?1 h?1) and turnover frequency (5.9 h?1) for at least 3 days.

Chiral 3 - morpholine methyl alcohol and 3 - morpholine a acid preparation method of the compound

The invention discloses a novel method for preparing chiral 3-morpholine methanol and 3-morpholine formic acid compounds. The method comprises the following steps: taking chiral serine as an initial material to obtain a serine ester (III) from a catalyst by esterification; reacting with halogen acetyl halide under an alkaline condition to obtain a compound (IV); obtaining a compound (V) by hydroxyl protection; adding a reducing agent to restore the ester into alcohol (VI); carrying out cyclization under the alkaline condition to obtain a compound (VII); obtaining a target product chiral 3-morpholine methanol compound (I) by amide reduction, hydroxyl deprotection and N protection; obtaining a chiral 3-morpholine formic acid compound (II) by oxidation. The method has the advantages of being low in cost, friendly to environment, simple to operate, high in yield, high in product purity and the like, the used reagent is simple and safe, and an intermediate in the reaction of each step does not need to be further purified, so that the experiment operation is greatly simplified, the production cost is reduced, and the method is applicable to industrial production.

Cleavable bifunctional coupling agents

A bifunctional coupling agent for joining a sulfhydryl containing protein or peptide and a metallic radionuclide comprising a sulfhydryl selective electrophile, a chelator containing at least one protected thiol and a organic linking radical containing at least one cleavable site which serves to join said electrophile and said chelator is disclosed. A radiodiagnostic or radiotherapeutic precursor comprising an antibody or antibody fragment and the specified bifunctional coupling agent bound to a sulfhydryl group on the antibody or antibody fragment and a radiodiagnostic or radiotherapeutic agent comprising such precursor having a metallic radionuclide bound thereto are also disclosed.