41179-33-3 Usage
Uses
Used in Research and Development:
2'-FLUORO-N-(4-HYDROXYPHENYL)-[1,1'-BIPHENYL]-4-BUTANAMIDE is used as a research compound for studying its chemical properties, potential interactions with biological systems, and possible applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2'-FLUORO-N-(4-HYDROXYPHENYL)-[1,1'-BIPHENYL]-4-BUTANAMIDE is used as a starting material or intermediate in the synthesis of various drugs and drug candidates. Its unique structure may provide novel pharmacological properties and potential therapeutic benefits.
Used in Diagnostic Applications:
2'-FLUORO-N-(4-HYDROXYPHENYL)-[1,1'-BIPHENYL]-4-BUTANAMIDE can be used as a diagnostic agent or a component in the development of diagnostic tools, taking advantage of its specific chemical and biological interactions.
Used in the Human Protein Atlas (HPA) project:
2'-FLUORO-N-(4-HYDROXYPHENYL)-[1,1'-BIPHENYL]-4-BUTANAMIDE may be utilized in the HPA project to study its interactions with various human proteins, contributing to the understanding of the human proteome at the tissue and subcellular levels.
Used in the Development of Monoclonal Antibodies:
In the context of monoclonal antibody development, 2'-FLUORO-N-(4-HYDROXYPHENYL)-[1,1'-BIPHENYL]-4-BUTANAMIDE could be employed as a component in the production of antibodies, such as the Monoclonal Anti-SOX9 antibody, which is used in immunofluorescence techniques.
Biological Activity
Non-ATP-competitive, selective inhibitor of p38 α -mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (apparent K i = 330 nM). Does not inhibit p38 α -mediated phosphorylation of the two other known p38 substrates, MBP and ATF-2.
Biochem/physiol Actions
Sex determining region Y box 9 (Sox9) participates in the human development processes. It helps to maintain the pluripotent cells at the time of pancreatic organogenesis. In adult tissues, Sox9 modulates stem and progenitor cells. Haploinsufficiency of Sox9 results in campomelic dysplasia (CD), a disease characterized by bowed femurs and tibiae, hypoplastic scapulae, 11 pairs of ribs, pelvic malformations, Robin sequence and clubbed feet.
Check Digit Verification of cas no
The CAS Registry Mumber 41179-33-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,1,7 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 41179-33:
(7*4)+(6*1)+(5*1)+(4*7)+(3*9)+(2*3)+(1*3)=103
103 % 10 = 3
So 41179-33-3 is a valid CAS Registry Number.
41179-33-3Relevant academic research and scientific papers
Davis, Terence,Bagley, Mark C.,Dix, Matthew C.,Murziani, Paola G.S.,Rokicki, Michal J.,Widdowson, Caroline S.,Zayed, Jameel M.,Bachler, Marcus A.,Kipling, David
, p. 6832 - 6835 (2007)
A benzopyranopyridine inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MK2) is prepared rapidly and efficiently in one step using microwave dielectric heating, whereas a substrate-selective p38 MAPK inhibitor was prepared using co
