412004-56-9Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold
Zhou, Zongtao,Cai, Zongyu,Zhang, Congzi,Yang, Benhui,Chen, Lianru,He, Yepu,Zhang, Luyong,Li, Zheng
, (2022/01/24)
The free fatty acid receptor 1 (FFA1/GPR40) and peroxisome proliferator-activated receptor δ (PPARδ) have been widely considered as promising targets for type 2 diabetes mellitus (T2DM) due to their respective roles in promoting insulin secretion and impr
CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE
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Paragraph 000801; 000802; 000876; 000877; 000879; 000880, (2018/01/17)
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.
Total synthesis of the resveratrol oligomers (±)-Ampelopsin B and (±)-σ-Viniferin
Lindgren, Anders E. G.,?berg, Christopher T.,Hillgren, J. Mikael,Elofsson, Mikael
supporting information, p. 426 - 429 (2016/02/18)
The total synthesis of the resveratrol dimers (±)-ampelopsin B and (±)-σ-viniferin is reported. Highlights of the approach include the use of cyclopropylmethyl groups to protect aromatic alcohols. This group allows an acid promoted three-step, one-pot dep
New pyrrolidine derivatives, pharmaceutical compositions and uses thereof
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Paragraph 0406-0409, (2014/04/18)
Pyrrolidine derivatives of the formula and their use as medicaments for the treatment of obesity and type 2 diabetes.
NEW PYRROLIDINE DERIVATIVES AND THEIR USE AS ACETYL-COA CARBOXYLASE INHIBITORS
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Page/Page column 79; 80, (2014/05/07)
The invention relates to new pyrrolidine derivatives of the formula (I) to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
NEW AZIRIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS ACETYL-COA CARBOXYLASE INHIBITORS
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Page/Page column 82, (2013/07/05)
The invention relates to new azetidine derivatives of the formula (I) wherein Ar1, Ar2, X, R, T and L are as defined in the description, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
AZETIDINE DERIVATIVES
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Paragraph 0495; 0496; 0497; 0498; 0499, (2013/06/28)
Azetidine derivatives of which the following is exemplary and their use in the treatment of obesity, diabetes or dyslipidemia.
New azetidine derivatives, pharmaceutical compositions and uses thereof
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Paragraph 0400; 0401; 0402; 0403; 0404, (2013/07/19)
The invention relates to new azetidine derivatives of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
NEW AZETIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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Page/Page column 72; 73, (2013/07/19)
The invention relates to new azetidine derivatives of the formula (I), to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
