412018-57-6Relevant academic research and scientific papers
Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α- oxo aldehyde as an electrophile
Hayashi, Yujiro,Yasui, Yusuke,Kojima, Masahiro,Kawamura, Tsuyoshi,Ishikawa, Hayato
supporting information; experimental part, p. 4570 - 4572 (2012/06/01)
The direct aldol reaction of an α-alkyl-α-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a γ-oxo-β-hydroxy-α-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity. The Royal Society of Chemistry 2012.
