412031-61-9Relevant academic research and scientific papers
Syntheses and antiinflammatory activity of new α-pyronochalcones, α-pyronoflavones and related products from 8-acetylumbelliferone
Khan,Bawa
, p. 1207 - 1214 (2007/10/03)
Fourteen new substituted α-pyronochalcones 4a-4n and five α-pyronoflavanones 5a-5e have been obtained from 8-acetylumbelliferone. The enone function of substituted α-pyronochalcones has been further exploited for the syntheses of α-pyronoflavones 6a-6c, pyrazolines 7a-7c, isoxazolines/isoxazoles 8a-8c, dihydroflavonol/flavonol 9a-9b, aminothiazole 11 and the Mannich base 12. Evaluation of these compounds for antiinflammatory activity against carrageenan induced rat's paw edema shows encouraging results.
