412272-22-1Relevant academic research and scientific papers
C2-symmetric bissulfoximines in palladium-catalyzed allylic alkylations
Bolm,Simi?,Martin
, p. 1878 - 1880 (2001)
C2-Symmetric bissulfoximines 2 have been used as chiral ligands in palladium-catalyzed asymmetric allylic alkylations. With 2c enantioselectivities of up to 98% ee have been achieved in the reaction of 1,3-diphenylpropenyl acetate with malonates as nucleophiles.
A mild synthetic procedure for the preparation of N-alkylated sulfoximines
Bolm, Carsten,Hackenberger, Christian P. R.,Simic, Oliver,Verrucci, Marinella,Mueller, Dirk,Bienewald, Frank
, p. 879 - 887 (2007/10/03)
N-Alkylated sulfoximines have been synthesized in good yields by acylation of NH-sulfoximines followed by carbonyl reduction with complexed boranes. Enantiopure substrates react without racemization, and stereogenic centers originating from the acylating component are retained. If the acylation is performed by DCC coupling, this two-step procedure represents a rare example of a formal N-alkylation of sulfoximines under base-free conditions.
