412293-43-7

Basic information

• Product Name: CarbaMic acid, (1-Methyl-4-oxocyclohexyl)-, 1,1-diMethylethyl ester
• Synonyms: CarbaMic acid, (1-Methyl-4-oxocyclohexyl)-, 1,1-diMethylethyl ester;carbamic acid, n-(1-methyl-4-oxocyclohexyl)-, 1,1-dimethylethyl ester;tert-Butyl (1-methyl-4-oxocyclohexyl)carbamate;tert-Butyl (1-methyl-4-oxocyclohexyl);tert-butyl N-(1-methyl-4-oxocyclohexyl)carbamate;(1-METHYL-4-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS NO: 412293-43-7
• Molecular Formula: C₁₂H₂₁NO₃
• Molecular Weight: 227.30004
• Mol File: 412293-43-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: CarbaMic acid, (1-Methyl-4-oxocyclohexyl)-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: CarbaMic acid, (1-Methyl-4-oxocyclohexyl)-, 1,1-diMethylethyl ester(412293-43-7)
• EPA Substance Registry System: CarbaMic acid, (1-Methyl-4-oxocyclohexyl)-, 1,1-diMethylethyl ester(412293-43-7)

Safety Data

• Hazardous Substances Data: 412293-43-7(Hazardous Substances Data)

Usage

Uses

N-(1-Methyl-4-oxocyclohexyl)-carbamic Acid 1,1-Dimethylethyl Ester is an intermediate used to prepare (S)-N-[N-cyclohexyl or N-(4-piperidinyl)glycyl]pyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors.

Upstream product

• 1342811-04-4 C₂₁H₄₃NO₃Si 
• 1342811-03-3 C₁₇H₃₄O₃Si 
• 1342811-02-2 C₁₆H₃₂O₃Si 
• 1352615-11-2 ethyl 4-triisopropylsilyloxycyclohexylcarboxylate 
• 792913-83-8 tert-butyl N-(4-hydroxy-1-methylcyclohexyl)carbamate 
• 3618-04-0 4-hydroxycyclohexyl carboxylic acid ethyl ester 
• 792913-82-7 tert-butyl 8-methyl-1,4-dioxaspiro[4,5]decane-8-carbamate 

Downstream Products

• 792913-83-8 tert-butyl N-(4-hydroxy-1-methylcyclohexyl)carbamate 
• 792913-89-4 tert-butyl 1-methyl-4-[(3-pyridinylmethoxy)imino]cyclohexylcarbamate 
• 1342811-05-5 C₁₇H₂₅BrN₄O₂ 
• 1254058-26-8 tert-butyl (4-amino-1-methylcyclohexyl)carbamate 

Relevant articles and documents

Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins

The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.

2-CYANOPYRROLIDINE DERIVATIVES AND THEIR USE AS DPP-IV INHIBITORS

A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X is CFH, or CF?2#191, R?1? is the moiety represented by the formula: [wherein R?2? is (lower) alkyl, R?3? is phenyl-(lower)alkyl, and the like.], and the like.] Compounds of formula (I) inhibit DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.