412295-15-9Relevant academic research and scientific papers
Practical synthesis of DQ-113, a new quinolone antibacterial agent, by using the intramolecular Horner-Wadsworth-Emmons reaction
Inagaki, Hiroaki,Takeda, Toshiyaki,Miyauchi, Rie N.,Kawakami, Katsuhiro,Takahashi, Hisashi,Takemura, Makoto
, p. 699 - 706 (2007/10/03)
A practical route was developed for synthesizing the C-7 substituent of DQ-113 (6, 5-amino-7-[(3S,4R)-4-(1-aminocycloprop-1-yl)-3-fluoropyrrolidin-1-yl] -6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-1, 4-dihydro-8-methyl-4-oxoquinolin-3-carboxylic acid),
DEHALOGENO COMPOUNDS
-
, (2008/06/13)
3-(1-Aminocycloalkyl)pyrrolidinyl-substituted-6-dehalodeno(hydrogen-substituted)quinolon carboxylic acid derivatives having specific substitunets as represented by the following formula (I), its salts, and hydrates thereof exhibit a broad and potent antibacterial activity on gram-negative and gram-positive bacteria, in particular, resistant bacteria typified by gram-positive cocci, including MRSA, PRSP and VRE . Thus these compounds are usable as drugs.
