412335-09-2

Upstream product

• 412335-07-0 7-benzyloxy-hept-4-ynoic acid 
• 412335-08-1 1-(2-benzo[1,3]dioxol-5-yl-ethyl)-5-(3-benzyloxy-1-hydroxy-propyl)-5-methoxy-pyrrolidin-2-one 
• 412335-02-5 7-benzyloxy-hept-4-ynoic acid (2-benzo[1,3]dioxol-5-yl-ethyl)-amide 
• 412335-03-6 N-[2-[3,4-(methylenedioxy)phenyl]ethyl]-5-[3-(benzyloxy)propyliden]pyrrolidin-2-one 
• 412335-06-9 7-benzyloxy-hept-4-yn-1-ol 
• 412335-04-7 10b-(3-benzyloxy-1-hydroxy-propyl)-1,4,5,10b-tetrahydro-2H-7,9-dioxa-3a-aza-dicyclopenta[a,g]naphthalen-3-one 

Downstream Products

• 412335-14-9 (+/-)-3,4-dehydro-3-dehydroxy-2-demethoxy-1,2-dihydro-2,8-dioxocephalotaxine 
• 412335-05-8 benzyl 3-oxo-4-[5,6,9,10-tetrahydro-8H-8-oxo-1,3-dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-11-yl]butanoate 

Relevant academic research and scientific papers

A formal total synthesis of (+/-)-cephalotaxine using sequential N-acyliminium ion reactions.

[reaction: see text] Novel synthesis of cephalotaxine 1 based on tertiary N-acyliminium ion chemistry starting from alkynylamide 2 was achieved. The key steps include the preparation of pyrroloisoquinoline 4 from alkynylamide 2, the ring expansion of pyrr