412335-18-3

Basic information

• Product Name: 4-(2-acetamido-3-oxobutyl)phenyl acetate
• CAS NO: 412335-18-3
• Molecular Weight: 263.293
• Mol File: 412335-18-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-acetamido-3-oxobutyl)phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-acetamido-3-oxobutyl)phenyl acetate(412335-18-3)
• EPA Substance Registry System: 4-(2-acetamido-3-oxobutyl)phenyl acetate(412335-18-3)

Safety Data

• Hazardous Substances Data: 412335-18-3(Hazardous Substances Data)

Usage

Class

Phenyl acetates (organic compounds)

Composition

Consists of a phenyl group attached to an acetamido-3-oxobutyl group

Common Uses

Research and chemical synthesis
Production of pharmaceuticals

Biological Activities

Anti-inflammatory properties
Analgesic properties

Potential Applications

Development of new drugs
Therapeutic agents

Upstream product

• 60-18-4 L-tyrosine 
• 17355-23-6 N-acetyl-O-acetyl-L-tyrosine 
• 108-24-7 acetic anhydride 
• 110-86-1 pyridine 

Downstream Products

• 63499-92-3 N-[1-(4-hydroxy-benzyl)-2-oxo-propyl]-acetamide 

Relevant articles and documents

The Enantioselective Dakin-West Reaction

Here we report the development of the first enantioselective Dakin-West reaction, yielding α-acetamido methylketones with up to 58 % ee with good yields. Two of the obtained products were recrystallized once to achieve up to 84 % ee. The employed methylimidazole-containing oligopeptides catalyze both the acetylation of the azlactone intermediate and the terminal enantioselective decarboxylative protonation. We propose a dispersion-controlled reaction path that determines the asymmetric reprotonation of the intermediate enolate after the decarboxylation.