412342-83-7

Upstream product

• 412342-75-7 (3S,4S,5S)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-((Z)-3-iodo-2-methyl-allyl)-4-methyl-dihydro-furan-2-one 
• 1026848-01-0 (4R,5S)-3-[(2R,3S,4S,5S,6S,7R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4-((Z)-3-iodo-2-methyl-allyl)-8-(4-methoxy-benzyloxy)-2,5,7-trimethyl-octanoyl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 412342-81-5 1-[(Z)-(2R,3S,4S,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-8-iodo-2,4,7-trimethyl-5-triethylsilanyloxymethyl-oct-7-enyloxymethyl]-4-methoxy-benzene 
• 412342-78-0 (3S,4S,5R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexanoic acid 
• 412342-74-6 (2S,3S,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-((Z)-3-iodo-2-methyl-allyl)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexanal 
• 412342-77-9 ((2R,3S,4S)-3-Benzyloxy-2,4-dimethyl-hex-5-enyloxy)-tert-butyl-diphenyl-silane 
• 412342-80-4 (2S,3S,4S,5R)-2-((Z)-3-Iodo-2-methyl-allyl)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexane-1,4-diol 
• 412342-79-1 (3S,4S,5S)-3-((Z)-3-Iodo-2-methyl-allyl)-5-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-4-methyl-dihydro-furan-2-one 
• 412342-76-8 (4S,5S)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-dihydro-furan-2-one 
• 412342-82-6 (4R,5S)-3-[(2R,3S,4S,5S,6S,7R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-((Z)-3-iodo-2-methyl-allyl)-8-(4-methoxy-benzyloxy)-2,5,7-trimethyl-3-triethylsilanyloxy-octanoyl]-4-methyl-5-phenyl-oxazolidin-2-one 

Downstream Products

• 412342-73-5 (2R,3S,4S,5S,6S,7R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-((Z)-3-iodo-2-methyl-allyl)-8-(4-methoxy-benzyloxy)-2,5,7-trimethyl-3-triethylsilanyloxy-octanal 
• 412342-87-1 (2E,4E)-(6S,7R,8S,9S,10S,11R)-10-(tert-Butyl-dimethyl-silanyloxy)-8-((Z)-3-iodo-2-methyl-allyl)-12-(4-methoxy-benzyloxy)-2,4,6,9,11-pentamethyl-7-triethylsilanyloxy-dodeca-2,4-dienoic acid ethyl ester 
• 412342-84-8 (E)-(4S,5R,6S,7S,8S,9R)-8-(tert-Butyl-dimethyl-silanyloxy)-6-((Z)-3-iodo-2-methyl-allyl)-10-(4-methoxy-benzyloxy)-2,4,7,9-tetramethyl-5-triethylsilanyloxy-dec-2-enoic acid ethyl ester 
• 412342-85-9 (E)-(4S,5R,6S,7S,8S,9R)-8-(tert-Butyl-dimethyl-silanyloxy)-6-((Z)-3-iodo-2-methyl-allyl)-10-(4-methoxy-benzyloxy)-2,4,7,9-tetramethyl-5-triethylsilanyloxy-dec-2-en-1-ol 
• 412342-86-0 (E)-(4S,5R,6S,7S,8S,9R)-8-(tert-Butyl-dimethyl-silanyloxy)-6-((Z)-3-iodo-2-methyl-allyl)-10-(4-methoxy-benzyloxy)-2,4,7,9-tetramethyl-5-triethylsilanyloxy-dec-2-enal 

Relevant academic research and scientific papers

A biosynthetic proposal for ring formation in the antitumor agent halichomycin. Asymmetric synthesis of the AB-carbon backbone of halichomycin.

[reaction: see text] A biosynthetic proposal for ring formation in the antitumor agent halichomycin is presented in which macrocyclization of the putative prehalichomycin intermediate 1 is the first step. Compound 2 then undergoes dehydration to the alpha