412351-03-2

Upstream product

• 579469-93-5 (S)-3-(3-Acetyl-5-bromo-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid methyl ester 
• 74-88-4 methyl iodide 
• 110774-03-3 L-3-(3-acetyl-4-hydroxyphenyl)-N-(benzyloxycarbonyl)alanine methyl ester 

Downstream Products

• 579469-94-6 (S)-3-(3-Acetoxy-5-bromo-4-methoxy-phenyl)-2-benzyloxycarbonylamino-propionic acid methyl ester 
• 579469-95-7 (S)-2-Benzyloxycarbonylamino-3-(3-bromo-5-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester 
• 579469-96-8 2-benzyloxycarbonylamino-3-[3-bromo-5-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-propionic acid methyl ester 
• 622336-95-2 2-benzyloxycarbonylamino-3-[5'-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-5-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-propionic acid methyl ester 
• 579469-84-4 3-[5'-(2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid 
• 579469-83-3 2-benzyloxycarbonylamino-3-[5'-(2-tert-butoxycarbonylamino-3-methoxymethoxy-propyl)-5-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-propionic acid methyl ester 
• 579469-89-9 (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-3-[5'-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propyl)-5-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-propionic acid methyl ester 
• 579469-90-2 (S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid 
• 579469-88-8 (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-3-[5'-((S)-2-tert-butoxycarbonylamino-3-methoxymethoxy-propyl)-5-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-propionic acid methyl ester 
• 579469-85-5 (2S,3S)-2-{(S)-3-[5'-((S)-2-Benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionylamino}-3-methyl-pentanoic acid benzyl ester 
• 412351-04-3 (S)-2-Benzyloxycarbonylamino-3-(3-bromo-5-hydroxy-4-methoxy-phenyl)-propionic acid 
• 412351-06-5 (9S,12S)-9-Benzyloxycarbonylamino-5-bromo-4-methoxy-17-nitro-10-oxo-2-oxa-11-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-12-carboxylic acid methyl ester 
• 412351-05-4 (S)-2-[(S)-2-Benzyloxycarbonylamino-3-(3-bromo-5-hydroxy-4-methoxy-phenyl)-propionylamino]-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of the (S,S,S)-diastereomer of the 15-membered biaryl ring system of RP 66453

The synthesis of the 15-membered biaryl ring system constituting an appropriately functionalized AB ring system of RP 66453 is detailed.

Preparation of the 14-membered L,L-cycloisodityrosine subunit of RP 66453

The synthesis of the reversed 14-membered L,L-cycloisodityrosine 9 constituting an appropriately functionalized BC ring system of RP 66453 is detailed.