4124-42-9

Basic information

• Product Name: ammonium toluene-4-sulphonate
• Synonyms: ammonium toluene-4-sulphonate;4-Toluenesulfonic acid ammonium salt;4-Methylbenzenesulfonic acid ammonium salt;Benzenesulfonic acid, 4-methyl-, ammonium salt;Benzenesulfonic acid, 4-methyl-, ammonium salt (1:1);Einecs 223-927-4
• CAS NO: 4124-42-9
• Molecular Formula: C₇H₈O₃S*H₃N
• Molecular Weight: 189.23214
• EINECS: 223-927-4
• Mol File: 4124-42-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 294.7 °C at 760 mmHg
• Flash Point: 132 °C
• Appearance: /
• Density: 1.34 g/cm³
• Vapor Pressure: 7.55E-07mmHg at 25°C
• CAS DataBase Reference: ammonium toluene-4-sulphonate(CAS DataBase Reference)
• NIST Chemistry Reference: ammonium toluene-4-sulphonate(4124-42-9)
• EPA Substance Registry System: ammonium toluene-4-sulphonate(4124-42-9)

Safety Data

• Hazardous Substances Data: 4124-42-9(Hazardous Substances Data)

Usage

General Description

Ammonium toluene-4-sulphonate is a chemical compound that is commonly used as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals and dyes. It is a white crystalline solid that is soluble in water and alcohol. Ammonium toluene-4-sulphonate is also used as a corrosion inhibitor in metalworking fluids and as a stabilizer in emulsion polymerization. It is known for its mild odor and is considered to be relatively low in toxicity, with no known carcinogenic or mutagenic effects. Overall, ammonium toluene-4-sulphonate is a versatile chemical with a wide range of industrial applications.

InChI:InChI=1/C7H8O3S.H3N/c1-6-2-4-7(5-3-6)11(8,9)10;/h2-5H,1H3,(H,8,9,10);1H3

Upstream product

• 932-90-1 syn-benzaldehyde oxime 
• 536-57-2 p-toluene sulfinic acid 
• 127-06-0 acetone oxime 
• 138883-24-6 ethyl 2-(2-aminothiazol-4-yl)-2-p-tosyloxyiminoacetate 
• 2365-48-2 Methyl thioglycolate 
• 138883-25-7 ethyl 2-(2-tritylaminothiazol-4-yl)-2-p-tosyloxyiminoacetate 
• 75-08-1 ethanethiol 
• 98-59-9 p-toluenesulfonyl chloride 
• 1418193-22-2 3-pyridinium-thietane p-toluenesulfonate 
• 109924-32-5 N-(tert-Butoxycarbonyl)-L-phenylalanyl-glycin-imidthiosaeure-S-ethylester 
• 100-53-8 phenylmethanethiol 
• 75057-16-8 N-(p-Tolylsulphonyloxy)-1-phenylnaphthalene-2,3-dicarboximide 

Downstream Products

• 87183-69-5 [Co(NH₂CH₂CH₂NH₂)2((⁽¹⁷⁾O)H₂)(O₃POC₆H₄NO₂)]⁽¹⁺⁾*SO₃C₆H₄CH₃^(1-)=[Co(NH₂CH₂CH₂NH₂)2((⁽¹⁷⁾O)H₂)(O₃POC₆H₄NO₂)](SO₃C₆H₄CH₃) 
• 87183-73-1 [Co(NH₂CH₂CH₂NH₂)2((⁽¹⁸⁾O)H₂)(O₃POC₆H₄NO₂)]⁽¹⁺⁾*C₇H₇SO₃^(1-)=[Co(NH₂CH₂CH₂NH₂)2((⁽¹⁸⁾O)H₂)(O₃POC₆H₄NO₂)]SO₃C₆H₄CH₃ 
• 455-16-3 p-toluenesulfonyl fluoride 
• 95012-36-5 Rh((C₆H₅)2PC₆H₄NH₂)2⁽¹⁺⁾*CH₃C₆H₄SO₃^(1-) 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF THIETANAMINE

The present invention provides processes for the preparation of compounds of formula (I) including processes comprising a. reacting a compound of formula (II) with a nucleophile in the presence of water to give a compound comprising a thietane moiety in which the carbon atom at the 3 position of the thietane moiety is bonded to a nitrogen atom; wherein the nucleophile is selected the group consisting of: N3-, a sulfonamide having two hydrogen atoms bound to the nitrogen atom, a diimide having a hydrogen atom bound to the nitrogen atom or an anion thereof, NH2OH and NH3; and b. when the nucleophile used in step a. is N3- or NH2OH, reacting the compound produced in step a. with a suitable reducing agent to give a compound of formula (I); or when the nucleophile used in step a. is a sulfonamide, reacting the compound produced in step a. with a reagent suitable for cleaving the S-N bond of the sulfonamide group to give a compound of formula (I); or when the nucleophile used in step a. is a diimide, reacting the compound produced in step a. with a reagent suitable for cleaving the C-N bond of the amide group to give a compound of formula (I). The invention also relates to intermediates useful for the preparation of compounds of formula (I).

Reaction of aminothiazole-oximetosylates with thiols

The reaction of ethyl 2-(2-aminothiazol-4-yl)-2-tosyloxyiminoacetate and its tritylamino analogue with thiols gave ethyl 2-(5-R-thio-2-amino- or tritylamino-thiazol-4-yl)-2-oxoacetate derivatives. Structures were elucidated by ir, 1H-, 13C-nmr and mass spectroscopy. A reaction mechanism is suggested.

Synthesis of Benzoquinazoline-2,4-diones via Lossen Rearrangement of N-(Arylsulphonyloxy)naphthalene-2,3-dicarboximide Derivatives

Treatment of N-(arylsulphonyloxy)-1-phenylnaphthalene-2,3-dicarboximides (IIa, b) with ammonia, aromatic amines, amino acids and hydrazine hydrate brings about the imide ring opening followed by Lossen rearrangement to give benzoquinazoline-2,4-diones (IIIa-h) and the salts of arylsulphonic acids (IVa-p).