41253-06-9

Basic information

• Product Name: Sulfamide, N,N'-bis(4-methylphenyl)-
• CAS NO: 41253-06-9
• Molecular Formula: C14H16N2O2S
• Molecular Weight: 276.359
• Mol File: 41253-06-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Sulfamide, N,N'-bis(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfamide, N,N'-bis(4-methylphenyl)-(41253-06-9)
• EPA Substance Registry System: Sulfamide, N,N'-bis(4-methylphenyl)-(41253-06-9)

Safety Data

• Hazardous Substances Data: 41253-06-9(Hazardous Substances Data)

Upstream product

• 104504-02-1 4-methyl-N-(tosyloxy)benzenesulfonamide 
• 106-49-0 p-toluidine 

Downstream Products

• 106-49-0 p-toluidine 

Relevant articles and documents

Efficient Synthesis of Unsymmetrical Sulfamides via a Lossen-Like Rearrangement

A convenient one-pot synthesis of unsymmetrical sulfamides via a Lossen-like rearrangement is reported. The protocol operates under simple conditions at room temperature and does not require an inert atmosphere and a dry solvent. The ability of N-hydroxy arenesulfonamide O-derivatives to generate under mild conditions N-sulfonylimine intermediates was a trigger point for developing a general synthetic strategy towards unsymmetrical sulfamides. The synthetic potential of the methodology has been investigated by preparing cyclic sulfamides and new potential chiral organocatalysts. (Figure presented.) .

Investigation of the acid-catalyzed hydrolysis and reaction mechanisms of N,N′-diarylsulfamides using various criteria

The mechanism of acid-catalyzed hydrolysis of a series of p-substituted N,N′-diarylsulfamides was investigated in aqueous mineral acid solutions. Rate profiles, reaction activation parameters, catalytic order of strong acids, solvent isotope effects, and analysis of the kinetic data by the excess acidity method suggest a change in the mechanism from A2 to A1. While the hydrolysis proceeds with an A2 mechanism in low acidity regions, an A1 mechanism takes place in high acid concentrations. Copyright

Sulfamides and sulfamide polymers directly from sulfur dioxide

SO2 gas is effectively used for the preparation of N,N′-diarylsulfamides and shape-persistent sulfamide polymers, which utilize a network of intermolecular N-H...O=S hydrogen bonds to self-assemble into soft porous materials. The Royal Society of Chemistry 2006.