41255-23-6

Basic information

• Product Name: 2-([1,1'-biphenyl]-4-yl)-3-hydroxy-4H-chromen-4-one
• Synonyms: 2-([1,1'-biphenyl]-4-yl)-3-hydroxy-4H-chromen-4-one
• CAS NO: 41255-23-6
• Molecular Weight: 314.34
• Mol File: 41255-23-6.mol

Chemical Properties

• CAS DataBase Reference: 2-([1,1'-biphenyl]-4-yl)-3-hydroxy-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-([1,1'-biphenyl]-4-yl)-3-hydroxy-4H-chromen-4-one(41255-23-6)
• EPA Substance Registry System: 2-([1,1'-biphenyl]-4-yl)-3-hydroxy-4H-chromen-4-one(41255-23-6)

Safety Data

• Hazardous Substances Data: 41255-23-6(Hazardous Substances Data)

Upstream product

• 41255-15-6 2'-Hydroxy-4-phenylchalkon 
• 118-93-4 o-hydroxyacetophenone 
• 3218-36-8 4-Phenylbenzaldehyde 

Downstream Products

• 1099682-23-1 C₂₈H₁₈F₂O₃ 
• 33322-67-7 N, N-dimethyl [1,1’-biphenyl]-4-carboxamide 
• 69-72-7 salicylic acid 
• 611-74-5 N,N-dimethylbenzamide 
• 92-92-2 biphenyl-4-carboxylic acid 

Relevant articles and documents

Novel bisbenzopyronopyran derivatives: photochemical synthesis and their in-vitro antimicrobial studies

The present research work describes the productive synthesis of novel bisbenzopyronopyran derivatives 4(a-h) and 5(a-h) via the photocyclization reactions of bischromones 3(a-h) under the inert conditions. The latter compounds have been realized efficiently through the O-alkylation reactions of the 3-hydroxychromone 2 with suitable dihalogenated aliphatic/aromatic/heteroaromatic reagents in the presence of dry acetone/anhydrous K2CO3/Bu4N+I? (PTC). The cyclization reaction of chalcone 1 under the Algar-Flynn-Oyamada reaction conditions (KOH/H2O2) could results in the formation of compound 2 in the good yield. The structural scaffolds of the newly prepared bischromones and resultant bisbenzopyronopyrans have been certified from the meticulous analysis of their various spectroscopic parameters such as UV-Vis, IR, 1H/13C-NMR, and ESI-MS. It was found that o/m/p-xylene and pyridine-linked final symmetrical bistetracycles exhibited higher antimicrobial potencies as compared to alkyl chain-linked cyclized products. The bischromones 3(a-h) could be able to endow modest level of antimicrobial behavior.

B-Ring-extended flavonol-based photoCORM: activated by cysteine-ratiometric fluorescence sensing and accurate control of linear CO release

The first B-ring-extended (to biphenyl) flavonol-based Cys-ratiometric fluorescent probeB-bph-fla-acr(2-([1,1′-biphenyl]-4-yl)-4-oxo-4H-chromen-3-yl acrylate) is developed.B-bph-fla-acrcan ratiometrically sense and non-ratiometrically image endogenous and exogenous cysteine (Cys) in living HeLa cells and zebrafish rapidly (45 s), selectively (vs.homocysteine and glutathione), sensitively (detection limit: 18.5 nM), and with a large Stokes shift (186 nm). Quantitatively released (from the reaction ofB-bph-fla-acrwith Cys) fluorophoreB-bph-fla-OH(2-([1,1′-biphenyl]-4-yl)-3-hydroxy-4H-chromen-4-one) is designed as a photoCORM (photo-triggered CO releasing molecule). Under O2and visible light irradiation, the amount of CO released byB-bph-fla-OHcan be accurately controlled linearly by adjusting the light irradiation intensity, irradiation time, or photoCORM dose. This process is accompanied by fluorescence quenching; therefore, the location of the photoCORM and the CO release process can be monitored in real time.B-bph-fla-acrand all reaction products exhibit good membrane permeability and low toxicity for living HeLa cells. In living HeLa cells and zebrafish,B-bph-fla-acrcan image endogenous and exogenous Cys, and the releasedB-bph-fla-OHcan photo-release CO under O2at room temperature. This study is the first to combine a B-ring-extended flavonol-based fluorescent probe (for the effective ratiometric sensing and non-ratiometric imaging of endogenous and exogenous Cysin vitroandin vivo) with a photoCORM (Cys-activated, visible light-triggered linear CO release under O2). Our study provides important insights into the biological roles of Cys and CO, as well as a reliable method for safely supplying accurately controlled amounts of CO to living systems, thereby facilitating the development of convenient clinical diagnostic molecular tools and therapeutic prodrugs.

Synthesis and characterization of some substituted chromones as an anti-infective and antioxidant agents

(Chemical Equation Presented) A series of substituted chromones were synthesized and characterized by spectral data. Some of the synthesized compounds were tested for in-vitro antibacterial, antifungal and antioxidant activity. Two compounds have shown ve

Syntheses and photophysical properties of fluorescent 2-aryl-3-hydroxy-4- chromenones

The particle detectors proposed for the Super-conducting Super Collider contain polystyrene scintillation fibers as a component. Scintillation fluors soluble in styrene are required which have improved light output and response time. New 2-aryl-3-hydroxy-