41265-84-3Relevant academic research and scientific papers
Amidation of esters assisted by Mg(OCH3)2 or CaCl2
Bundesmann, Mark W.,Coffey, Steven B.,Wright, Stephen W.
experimental part, p. 3879 - 3882 (2010/08/19)
Magnesium methoxide (Mg(OCH3)2) and calcium chloride have been shown to facilitate the direct aminolysis of esters by ammonia to primary amides. Methyl, ethyl, isopropyl, and tert-butyl esters were converted to the corresponding carboxamides in good yields. Reactions have been run on a larger scale and without the safety liability inherent in the use of magnesium nitride (Mg3N2). Ammonium chloride and amine hydrochlorides have been used successfully in the place of ammonia with magnesium methoxide.
Magnesium nitride as a convenient source of ammonia: Preparation of primary amides
Veitch, Gemma E.,Bridgwood, Katy L.,Ley, Steven V.
scheme or table, p. 3623 - 3625 (2009/05/07)
(Chemical Equation Presented) The use of magnesium nitride (Mg 3N2) as a convenient source of ammonia has been explored for the direct transformation of esters to primary amides. Methyl, ethyl, isopropyl, and tert-butyl esters are converted to the corresponding carboxamides in good yields (75-99%).
