41270-75-1Relevant academic research and scientific papers
A CONVENIENT AND NEW ONE-STEP SYNTHESIS OF 1H-IMIDAZOLE-2-CARBOXAMIDES
Singh, Baldev
, p. 2373 - 2378 (2007/10/02)
1,2-Diketone monophenylhydrazones (2) reacted with aminomalonamide in 1-methyl-2-pyrrolidinone to provide 1H-imidazole-2-carboxamides (4).The condensation of 1-(4-pyridinyl)-2-propanone with phenyldiazonium chloride gave 1-phenylhydrazono-1-(4-pyridinyl)-2-propanone (2a). 4-Methyl-5-(4-pyridinyl)-1H-imidazole-2-carboxamide (4a) was converted to the corresponding nitrile (5a) by the action of phosphorous oxychloride.
