41270-96-6 Usage
Uses
Used in Pharmaceutical Industry:
4-IODO-6-PHENYLPYRIMIDINE is used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assays. This application is particularly relevant in the development of new drugs and therapies targeting immune system-related conditions and diseases.
In the context of the provided materials, 4-IPP serves as a crucial component in the study of macrophage migration, which is an essential process in the immune response. By inhibiting the migration of macrophages, researchers can better understand the underlying mechanisms and develop targeted treatments for various immune-related disorders.
Biological Activity
Inhibitor of macrophage migration inhibitor factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo . Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro .
Biochem/physiol Actions
4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.
Check Digit Verification of cas no
The CAS Registry Mumber 41270-96-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,2,7 and 0 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 41270-96:
(7*4)+(6*1)+(5*2)+(4*7)+(3*0)+(2*9)+(1*6)=96
96 % 10 = 6
So 41270-96-6 is a valid CAS Registry Number.
