41284-92-8 Usage
General Description
5-Iodophthalide is a chemical compound with the molecular formula C8H5IO2. It is a yellow solid that is commonly used in organic synthesis and pharmaceutical research. 5-Iodophthalide is a derivative of phthalic anhydride and is known for its unique and valuable properties, such as its ability to act as a precursor for various pharmaceutical intermediates. It is also used as a building block in the synthesis of biologically active compounds and has potential applications in the development of new drugs. Additionally, 5-Iodophthalide is a valuable reagent for the synthesis of complex organic molecules, making it an important and versatile chemical in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 41284-92-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,2,8 and 4 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 41284-92:
(7*4)+(6*1)+(5*2)+(4*8)+(3*4)+(2*9)+(1*2)=108
108 % 10 = 8
So 41284-92-8 is a valid CAS Registry Number.
41284-92-8Relevant articles and documents
Diarylthiophenes as inhibitors of the pore-forming protein perforin
Miller, Christian K.,Huttunen, Kristiina M.,Denny, William A.,Jaiswal, Jagdish K.,Ciccone, Annette,Browne, Kylie A.,Trapani, Joseph A.,Spicer, Julie A.
, p. 355 - 360 (2016/01/09)
Evolution from a furan-containing high-throughput screen (HTS) hit (1) resulted in isobenzofuran-1(3H)-one (2) as a potent inhibitor of the function of both isolated perforin protein and perforin delivered in situ by intact KHYG-1 NK cells. In the current study, structure-activity relationship (SAR) development towards a novel series of diarylthiophene analogues has continued through the use of substituted-benzene and -pyridyl moieties as bioisosteres for 2-thioxoimidazolidin-4-one (A) on a thiophene (B) -isobenzofuranone (C) scaffold. The resulting compounds were tested for their ability to inhibit perforin lytic activity in vitro. Carboxamide (23) shows a 4-fold increase(2) in lytic activity against isolated perforin and provides good rationale for continued development within this class.
