4129-20-8 Usage
Uses
Used in Organic Synthesis:
Phosphinothioic azide, diphenylis used as a reagent for the conversion of carboxylic acids to the corresponding acid chlorides, which are essential intermediates in a wide range of organic reactions.
Used in the Synthesis of Amides and Esters:
DPPA is utilized in the synthesis of amides and esters, which are important functional groups in organic chemistry and have applications in various industries, including pharmaceuticals and materials science.
Used in Research and Development:
Phosphinothioic azide, diphenylis employed in research and development for the exploration of new synthetic pathways and the development of novel organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, DPPA is used as a reagent for the synthesis of various drug molecules, contributing to the discovery and development of new therapeutic agents.
Used in Material Science:
In material science, DPPA is used in the synthesis of advanced materials, such as polymers and composites, with specific properties tailored for various applications.
Safety Precautions:
Caution must be exercised when handling Phosphinothioic azide, diphenyldue to its reactivity and potential hazards. Proper safety measures, including the use of personal protective equipment and handling in well-ventilated areas, should be followed to minimize risks.
Check Digit Verification of cas no
The CAS Registry Mumber 4129-20-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,2 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4129-20:
(6*4)+(5*1)+(4*2)+(3*9)+(2*2)+(1*0)=68
68 % 10 = 8
So 4129-20-8 is a valid CAS Registry Number.
4129-20-8Relevant academic research and scientific papers
New methods and reagents in organic synthesis. 35. A new synthesis of some non-steroidal anti-inflammatory agents with the 2-arylpropionic acid skeleton by the use of diphenyl phosphorazidate (DPPA) as a 1,3-dipole
Kawai,Kato,Hamada,Shioiri
, p. 3139 - 3148 (2007/10/02)
Reaction of diphenylphosphonic azide (8) with the pyrrolidine enamine 13 of 4-isobutylpropiophenone afforded two amidines 15a and 16a, which were derived from the 1,3-dipolar cycloadduct 14a by the expulsion of nitrogen followed by 1,2-aryl migration (path a) and by 1,3-dipolar elimination (path b), respectively. Although diphenylthiophosphinic azide (9) and ethyl phenylthiophosphonoazidate (10) also gave similar results, diphenylphosphorazidate (DPPA, (C6H5O)2P(O)N3) furnished the amidine 15d formed via path a as the sole isolable product. Hydrolysis of 15d with potassium hydroxide afforded ibuprofen (3) in good yield. Other nonsteroidal antinflammatory agents, naproxene (4), ketoprofen (5), and flurbiprofen (6), were analogously and conveniently prepared from the ketones 17, 22, and 25, respectively, by a similar three-step operation using pyrrolidine, DPPA, and potassium hydroxide. 2-(2-Dibenzofuranyl)-propionic acid (7) was also prepared from the ketone 28 by the three-step procedure.
