41295-62-9Relevant academic research and scientific papers
A naphtho[2,1-b]furan as a new fluorescent label: Synthesis and spectral characterisation
Piloto, Ana M.,Costa, Susana P. G.,Gon?alves, M. Sameiro T.
, p. 4757 - 4760 (2005)
A fluorescent naphthofuran was synthesised from an oxobenzopyran by alkaline ring contraction and coupled with various l-amino acids at their N-terminus or at side-chain functional groups, in order to evaluate its applicability as a fluorescent label for
Design and synthesis of tailored human caseinolytic protease P inhibitors
Gronauer, Thomas F.,Mandl, Melanie M.,Lakemeyer, Markus,Hackl, Mathias W.,Me?ner, Martina,Korotkov, Vadim S.,Pachmayr, Johanna,Sieber, Stephan A.
supporting information, p. 9833 - 9836 (2018/09/10)
Human caseinolytic protease P (hClpP) is important for degradation of misfolded proteins in the mitochondrial unfolded protein response. We here introduce tailored hClpP inhibitors that utilize a steric discrimination in their core naphthofuran scaffold to selectively address the human enzyme. This novel inhibitor generation exhibited superior activity compared to previously introduced beta-lactones, optimized for bacterial ClpP. Further insights into the bioactivity and binding to cellular targets were obtained via chemical proteomics as well as proliferation- and migration studies in cancer cells.
Synthesis of novel coumarin and benzocoumarin derivatives and their biological and photophysical studies
Abd-El-Aziz, Alaa S.,Mohamed, Hany M.,Mohammed, Shawkat,Zahid, Shamsulhaq,Ata, Athar,Bedair, Ahmed H.,El-Agrody, Ahmed M.,Harvey, Pierre D.
, p. 1287 - 1301 (2008/09/18)
(Chemical Equation Presented) Several derivatives of coumarin-3N- carboxamides (3-21) have been prepared via the reaction of the coumarin-3-carbonyl chloride (1) with a number of nucleophiles. Novel double-headed coumarin-3N-carboxamides (26-33) were also produced using the same method. The Pechmann-Duisberg reaction was applied to prepare new benzo[f]- benzo[h]coumarins and 4-(chloromethyl)-pyrano[3,2-c]coumarin-2-one (36-42). The reaction of 1-chloromethylbenzo[f]coumarins (36) with cyanide anion under different reaction conditions was also investigated in order to assess its suitability for nucleophilic substitution reactions as well as ring transformation products (43-49). Synthesis of 1-((benzo[d]thiazol-2-yl)methyl)- 9-hydroxybenzo[f]coumarin (50) represented the first example of methylene bridge-head heterocycle-containing benzo[f]coumarin. Some of the newly prepared coumarins exhibited anti-bacterial activity against Gram Positive and Gram negative bacteria. Compound 36d was found to be active against all the screened bacteria. Photophysical studies were performed on selected fluorescent benzo[f]- and benzo[h]coumarin and the quantum yields were also calculated. All new compounds were characterized by IR, MS, 1H and 13C NMR, as well as elemental analysis.
Carboxylic fused furans for amino acid fluorescent labelling
Piloto, Ana M.,Fonseca, Andrea S.C.,Costa, Susana P.G.,Gon?alves, M. Sameiro T.
, p. 9258 - 9267 (2007/10/03)
Four carboxylic fused furans are presented as new fluorescent labels for the amino and hydroxyl functions of organic molecules. Various representative l-amino acids were chosen as models, labelled at their N-terminus and also at their side-chain. Fluoresc
Synthesis of 2-nitronaphtho [2,1-b] furan carboxylic acids derivatives
Einhorn,Lamotte,Buisson,et al.
, p. 143 - 147 (2007/10/02)
2-Nitro naphthofurans carrying a carboxyl group, an acetyl or oxy acetyl chain outer homocycle are obtained - either directly or through their ester - by condensations of bromonitromethane with suitably substituted ortho hydroxy naphthoic aldehydes. 2-Nitro naphthofuran, which bears an acetyl chain on the second carbon of its heterocycle, is formed by direct nitration of the acid or of a (naphtho[2,1-b]-3-furyl)-ecetic ester. These acids and their corresponding esters are nearly always less active against bacteria and protozoa than the reference 2-nitro naphthofurans.
