41298-49-1

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Phenoxypropyl)piperazine is used as an intermediate in the synthesis of various pharmaceuticals for its potential antiviral, antipsychotic, and antihistaminic properties. Its diverse pharmacological activities make it a valuable compound in the development of new medications.
Used in Agrochemical Industry:
1-(3-Phenoxypropyl)piperazine is also used as an intermediate in the synthesis of agrochemicals, contributing to the development of products for agricultural applications.
Used in Research and Development:
In the research and development sector, 1-(3-Phenoxypropyl)piperazine is utilized to explore its potential therapeutic applications, including its antiviral, antipsychotic, and antihistaminic properties. This exploration aids in the advancement of medical and chemical knowledge and the creation of novel treatment options.

InChI:InChI=1/C13H20N2O/c1-2-5-13(6-3-1)16-12-4-9-15-10-7-14-8-11-15/h1-3,5-6,14H,4,7-12H2

Upstream product

• 110-85-0 piperazine 
• 3384-04-1 3-chloropropyl phenyl ether 
• 588-63-6 3-phenoxypropyl bromide 
• 1384256-96-5 tert-butyl 4-(3-phenoxypropyl)piperazine-1-carboxylate 

Downstream Products

• 138539-94-3 6-[4-(3-phenoxypropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.hydrochloride 
• 1179874-30-6 8-chloro-11-[4-(3-phenoxypropyl)piperazino]5H-dibenzo[b,e][1,4]diazepine 
• 1384256-86-3 biphenyl-4-yl 3-(4-(3-phenoxypropyl)piperazin-1-yl)acrylate 
• 1383806-58-3 C₁₆H₂₃N₃O 
• 145708-24-3 1-(3-aminopropyl)-4-[3-(phenoxy)propyl]piperazine 

Relevant academic research and scientific papers

SINGLET OXYGEN-LABILE LINKERS AND METHODS OF PRODUCTION AND USE THEREOF

Activatable compositions that include at least one functional moiety and at least one cleavable linker directly or indirectly linked to the at least one functional moiety are disclosed. The at least one functional moiety is inactive when linked to the linker and activated upon cleavage of the linker. Methods of production and use of the activatable composition are also disclosed.

1-Phenoxyalkyl-4-[(N,N-disubstitutedamino)alkyl]piperazine derivatives as non-imidazole histamine H3-antagonists

In this study, a series of 1-phenoxyalkyl-4-[(N,N-disubstitutedamino)alkyl] piperazine derivatives has been prepared and in vitro tested as H 3-receptor antagonists (electrically evoked contraction of the guinea pig jejunum). All compounds inve

Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release

"Click and Photo-unclick Chemistry" of aminoacrylates is proposed for a new photo-labile linker. Adducts are built in 2 steps with good yields and cleaved rapidly by tissue penetrable visible light (690 nm) with a photosensitizer. Facile synthesis, release of mother drug, and stability and cleavage in medium are demonstrated.

New azoles with potent antifungal activity: Design, synthesis and molecular docking

In response to the urgent need for novel antifungal agents with improved activity and broader spectrum, computer modeling was used to rational design novel antifungal azoles. On the basis of the active site of lanosterol 14α-demethylase from Candida albicans (CACYP51), a series of new azoles with substituted-phenoxypropyl piperazine side chains were rational designed and synthesized. In vitro antifungal activity assay indicates that the new azoles show good activity against most of the tested pathogenic fungi. Interestingly, the designed compounds are also active against an azole-resistant clinical strain. Compared to fluconazole and itraconazole, several compounds (such as 12i, 12j and 12n) show higher antifungal activity and broader spectrum, which are promising leads for the development of novel antifungal agents.

Synthesis and preliminary pharmacological evaluation of 4′-arylalkyl analogues of clozapine. IV. the effects of aromaticity and isosteric replacement

We report the synthesis and preliminary pharmacological activity of a new series of tricyclic analogues of clozapine as potential antipsychotic agents for the treatment of schizophrenia. These compounds were designed based on a revised structural model, a

Piperazine alkanols

This invention relates to variously substituted piperazine derivatives. S compounds possess therapeutically useful vasodilator properties.