41302-05-0Relevant articles and documents
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Spiegelberg,Doebel
, p. 283,287 (1956)
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Donepezil–melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments
?ozińska, Iwona,?wierczyńska, Aleksandra,Mol?da, Zuzanna,Hartman, Alwin M.,Hirsch, Anna K. H.,Czarnocki, Zbigniew
, (2018/10/15)
Hybrid inhibitors of acetyl- and butyrylcholinesterase are compounds that combine structural motifs of two different classical inhibitors, leading to a dual binding ligand. A rapidly growing collection of those compounds involves a wide diversity of structural motifs, but the way of linking two active fragments and its impact on the affinity toward cholinesterases usually remains beyond the extent of investigation. We present hereby a detailed analysis of this aspect using melatonin–donepezil hybrids. A new series of compounds, in which two fragments are connected using a carbamate linker, exhibits excellent activity and selectivity toward butyrylcholinesterase.
POLYMERIZABLE COMPOUND AND OPTICAL ANISOTROPIC BODY
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Paragraph 0156-0158, (2018/09/30)
PROBLEM TO BE SOLVED: To provide a polymerizable compound having high storage stability without causing precipitation of crystals or the like when added to a polymerizable composition and large refractive index anisotropy and to provide a polymerizable composition which hardly causes haze when polymerized by attaching a resin mold to a polymerizable composition containing the polymerizable compound. SOLUTION: There are provided: a compound represented by the formula (I), for example, a compound represented by the formula (I-106); a composition containing the compound; a polymer obtained by polymerizing the compound; and an optical anisotropic body using the polymer. COPYRIGHT: (C)2016,JPOandINPIT