41339-64-4Relevant academic research and scientific papers
E-SELECTIN ANTAGONISTS
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Page/Page column 47, (2012/04/04)
Compounds, compositions and methods are provided for inhibiting in vitro and in vivo processes mediated by E-selectin binding. More specifically, particular glycomimetic compounds are described, wherein the compounds are E- selectin antagonists.
A fragment-based in situ combinatorial approach to identify high-affinity ligands for unknown binding sites
Shelke, Sachin V.,Cutting, Brian,Jiang, Xiaohua,Koliwer-Brandl, Hendrik,Strasser, Daniel S.,Schwardt, Oliver,Kelm, Soerge,Ernst, Beat
supporting information; experimental part, p. 5721 - 5725 (2010/11/02)
[Figure Presented] In the lead: The title method for the identification of ligands is particularly useful for binding sites where little or no structural information is available. In a fragment-based approach, a suitable pair of first- and second-site ligands is identiled by NMR experiments. By applying a receptor-mediated in situ combinatorial approach, the two ligands are then linked to generate a new high-affinity lead structure (see picture).
First heterogeneous ligand- and salt-free larock indole Synthesis
Batail, Nelly,Bendjeriou, Anissa,Lomberget, Thierry,Barrett, Roland,Dufaud, Veronique,Djakovitch, Laurent
supporting information; experimental part, p. 2055 - 2062 (2009/12/26)
A new ligand- and salt-free procedure using heterogeneous palladium catalysts for the Larock indole and benzofuran synthesis is reported. After optimisation of the reaction conditions, good to high isolated yields have been achieved for a variety of structures. Recycling studies have shown that the palladium catalysts can be readily recovered and reused. Reactions and recovery of the palladium catalysts can be carried out in the presence of air, without any particular precaution.
ANTIMIGRAINE CYCLOBUTENEDIONE DERIVATIVES OF TRYPTAMINES
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, (2008/06/13)
A series of serotonergic 5-cyclobutenedionylamino-substituted tryptamine derivatives of Formula I is disclosed for use in the alleviation of vascular headaches. STR1 The formula I substituents, as further defined in the specification, are: R 1 is hydrogen, halogen, and alkyl; R 2 and R 3 can be hydrogen or alkyl; R 4 is hydrogen, alkyl, acyl or alkylsulfonyl; m is 0 to 3 and n is 1 to 5; and X is amino, alkoxy, hydrogen, alkyl, aryl or alkylaryl.
Indolylalkylpiperidines
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, (2008/06/13)
1-(Indolyl-3-alkyl)-3 or 4-(ureido or guanidino)-piperidines, e.g. those of the formula STR1 R= H; alkyl; free, etherified or esterified OH or SH; CF3, NO2 or NH2 m= 1-4; n= 2 or 3; X= O, S or NH acyl derivatives and salts thereof are antihypertensive agents.
