41339-83-7

Upstream product

• 41339-61-1 5-benzyloxy-3-(2-hydroxyethyl)indole 
• 141-97-9 ethyl acetoacetate 
• 135873-16-4 (6-benzyloxy-1-methyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid ethyl ester 

Downstream Products

• 41340-04-9 6-hydroxy-1-methyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid benzylamine salt 
• 42820-44-0 (6-benzyloxy-1,9-dimethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid 

Relevant academic research and scientific papers

Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase

This invention relates to substituted indole derivatives possessing lipoxygenase inhibitory, phospholipase A2 inhibitory and leukotriene antagonist activity, which are useful as anti-inflammatory, antiallergic and cytoprotective agents.

SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE-ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE

There are disclosed compounds of the formula A(CH2)nO-B and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.

Pyrano- and thiopyranoindole derivatives, compositions and methods of use

Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 positio

A novel class of potential antidepressants: 1 aminoalkyl 1,3,4,9 tetrahydropyrano [3,4 b]indoles

A series of twenty four 1,3,4,9 tetrahydropyrano[3,4 b]indoles bearing baic side chains at positions 1 or 9 have been synthesized and their acute toxicities and antidepressant properties have been determined. One of the most active compounds was 1,9 dimethyl 1 [2 (dimethylamino)ethyl] 1,3,4,9 tetrahydropyrano[3,4 b]indole hydrochloride (AY 23,671), having an ED50 of 0.51 mg/kg i.p. in mice in preventing reserpine induced ptosis. The enantiomers of this compound were examined and were found to have the same order of activity as the racemate.