41341-59-7Relevant academic research and scientific papers
Total synthesis of LeA-LacNAc pentasaccharide as a ligand for Clostridium difficile toxin A
Zhang, Ping,Ng, Kenneth,Ling, Chang-Chun
supporting information; experimental part, p. 128 - 136 (2010/05/02)
The toxins TcdA and TcdB produced by the human pathogen Clostridium difficile gain entrance to host epithelial cells by recognizing cell-surface carbohydrate ligands. Inhibiting the attachment of these toxins to host cells has been proposed to be a viable
Stereoselective iterative one-pot synthesis of N-glycolylneuraminic acid-containing oligosaccharides
Crich, David,Wu, Baolin
supporting information; experimental part, p. 4033 - 4035 (2009/06/18)
(Chemical Equation Presented) The use of an N-acyloxazolidinone-protected S-adamantanyl thiosialoside allows the highly stereoselective, one-pot multicomponent synthesis of α-slaloside-based oligosaccharides.
A convenient preparation of glycosyl chlorides from aryl/alkyl thioglycosides
Sugiyama, Shin,Diakur, James M.
, p. 2713 - 2715 (2007/10/03)
(equation presented) Because of the vast structural diversity encountered in the field of glycobiology, versatile methods for orthogonal oligosaccharide assembly are always of interest. Reported herein is the preparation of glycosyl chloride donors obtained by reaction of the corresponding thioglycoside precursors with chlorosulfonium chloride reagent 4. The crude chlorides thus obtained can be used directly in subsequent glycosylation reactions, and examples of the generality of this approach are provided.
