41346-39-8

Basic information

• Product Name: chloroanhydride of the p-fluorophenyl ester of N,N-bis(2-chloroethyl)amidophosphoric acid
• Synonyms: chloroanhydride of the p-fluorophenyl ester of N,N-bis(2-chloroethyl)amidophosphoric acid
• CAS NO: 41346-39-8
• Molecular Weight: 334.542
• Mol File: 41346-39-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: chloroanhydride of the p-fluorophenyl ester of N,N-bis(2-chloroethyl)amidophosphoric acid(CAS DataBase Reference)
• NIST Chemistry Reference: chloroanhydride of the p-fluorophenyl ester of N,N-bis(2-chloroethyl)amidophosphoric acid(41346-39-8)
• EPA Substance Registry System: chloroanhydride of the p-fluorophenyl ester of N,N-bis(2-chloroethyl)amidophosphoric acid(41346-39-8)

Safety Data

• Hazardous Substances Data: 41346-39-8(Hazardous Substances Data)

Upstream product

• 127-88-8 N,N-di(2-chloroethyl)amidophosphoric acid dichloride 
• 371-41-5 4-Fluorophenol 

Downstream Products

• 41346-43-4 N,N-bis-(2-chloro-ethyl)-P-morpholin-4-yl-phosphonamidic acid 4-fluoro-phenyl ester 
• 81175-75-9 C₁₄H₂₂Cl₂FN₂O₄P 
• 81175-83-9 C₁₆H₂₆Cl₂FN₂O₈PS₂ 
• 41346-50-3 N,N-bis-(2-chloro-ethyl)-N'-(4-thiazol-2-ylsulfamoyl-phenyl)-phosphorodiamidic acid 4-fluoro-phenyl ester 

Relevant articles and documents

Synthesis and Antitumor Effect of Sophoridine Derivatives Bearing an Acyclic Aryloxy Phosphoramidate Mustard Functionality

To elevate the potency of sophoridine, phosphoramidate mustard motif was incorporated to D-ring opened sophoridine scaffold. A series of acyclic aryloxy phosphoramidate mustard functionalized sophoridine derivatives were synthesized and screened for cytostatic activity in a range of different tumor cell lines (S180, H22, K562, MCF-7, SMMC-7721, and LoVo). All these compounds were shown to be more sensitive to S180 and H22 cells with IC50 values ranging from 2.10 to 7.21?μM. In addition, all targeted derivatives distinctly are more cytotoxic to cancer cells than normal cell L929. Compounds 8b, 8c, 8d, and 8e displayed moderate tumor suppression without apparent organ toxicity in vivo against mice bearing H22 liver tumors. Their potential binding modes with DNA topoisomerase I complex have also been investigated.