413571-27-4Relevant articles and documents
Stereoselective synthesis of 22-oxacalcitriol (OCT) and analogues modified at C25
Fall, Yagamare,González, Victoria,Vidal, Beatriz,Mouri?o, Antonio
, p. 427 - 429 (2007/10/03)
The stereoselective synthesis of 22-oxacalcitriol (OCT) has been achieved. The triene system was introduced using the Lythgoe-Hoffmann La Roche convergent Wittig-Horner approach to couple ketoester 7 with A ring phosphine oxide 8. The value of the resulting ester 6 for synthesis of C25-modified OCT analogues is exemplified by the synthesis of 5.