41359-01-7

Basic information

• Product Name: N-(phenylmethyl)-5H-dibenz[b,f]azepine-5-carboxamide
• Synonyms: N-(phenylmethyl)-5H-dibenz[b,f]azepine-5-carboxamide
• CAS NO: 41359-01-7
• Molecular Weight: 326.398
• Mol File: 41359-01-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(phenylmethyl)-5H-dibenz[b,f]azepine-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(phenylmethyl)-5H-dibenz[b,f]azepine-5-carboxamide(41359-01-7)
• EPA Substance Registry System: N-(phenylmethyl)-5H-dibenz[b,f]azepine-5-carboxamide(41359-01-7)

Safety Data

• Hazardous Substances Data: 41359-01-7(Hazardous Substances Data)

Upstream product

• 33948-22-0 5H-dibenz[b,f]azepine-5-carbonylchloride 
• 100-46-9 benzylamine 

Relevant articles and documents

Carbamazepine derivatives with P2X4 receptor-blocking activity

Antagonists for the P2 receptor subtype P2X4, an ATP-activated cation channel receptor, have potential as novel drugs for the treatment of neuropathic pain and other inflammatory diseases In the present study, a series of 47 carbamazepine derivatives including 32 novel compounds were designed, synthesized, and evaluated as P2X4 receptor antagonists Their potency to inhibit ATP-induced calcium influx in 1321N1 astrocytoma cells stably transfected with the human P2X4 receptor was determined Additionally, species selectivity (human, rat, mouse) and receptor subtype selectivity (P2X4 vs P2X1, 2, 3, 7) were investigated for selected derivatives The most potent compound of the present series, which exhibited an allosteric mechanism of P2X4 inhibition, was N,N-diisopropyl-5H-dibenz[b,f]azepine-5-carboxamide (34, IC50 of 3.44 μM) The present study extends the so far very limited knowledge on structure-activity relationships of P2X4 receptor antagonists