413601-58-8

Basic information

• Product Name: Methanediol, (2,4,6-trimethylphenyl)-, diacetate
• CAS NO: 413601-58-8
• Molecular Formula: C14H18O4
• Molecular Weight: 250.295
• Mol File: 413601-58-8.mol

Chemical Properties

• CAS DataBase Reference: Methanediol, (2,4,6-trimethylphenyl)-, diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methanediol, (2,4,6-trimethylphenyl)-, diacetate(413601-58-8)
• EPA Substance Registry System: Methanediol, (2,4,6-trimethylphenyl)-, diacetate(413601-58-8)

Safety Data

• Hazardous Substances Data: 413601-58-8(Hazardous Substances Data)

Upstream product

• 487-68-3 mesytaldehyde 
• 108-24-7 acetic anhydride 

Downstream Products

• 92035-54-6 1-(2,4,6-trimethylphenyl)-3-buten-1-ol 
• 63548-92-5 2,4,6-trimethylbenzyl acetate 

Relevant articles and documents

Lithium trifluoromethanesulfonate (LiOTf) as a recyclable catalyst for highly efficient acetylation of alcohols and diacetylation of aldehydes under mild and neutral reaction conditions

A variety of alcohols and aldehydes were reacted with acetic anhydride at room temperature in the presence of a catalytic amount of lithium triflate (LiOTf) to produce the corresponding esters and 1,1-diacetates, respectively, in good to excellent yields under essentially neutral reaction conditions. Sensitive functional groups such as PhCO2-, OMe, and OTBDMS ethers survived intact under the described reaction conditions.

Reductive esterification of aromatic aldehydes using Zn/Ac 2O/imidazole or Zn/Yb(OTf)3/(RCO)2O system

Benzaldehydes are reduced by metallic zinc in the presence of Ac 2O and imidazole, giving the corresponding benzyl acetates in good yields. Reductive esterification of aromatic aldehydes is also carried out via gem-diacetoxy compounds. Carbonyl compounds are readily converted to the gem-diacyloxy compounds in excellent yields on treatment with 2molar amounts of acid anhydride and 10mol% of Yb(OTf)3 in MeCN at room temperature. Thus-formed diacyloxy compounds derived from aromatic aldehydes are reduced in situ by metallic zinc to afford the corresponding esters.

Conversion of aldehydes into geminal dicarboxylates (acylals) catalyzed by lithium tetrafluoroborate

A variety of aldehydes react with acid anhydrides in the presence of a catalytic amount of lithium tetrafluoroborate to afford the corresponding geminal dicarboxylates (acylals) in good to excellent yields.

An efficient method for diacetylation of aldehydes

Cu(OTf)2 was found to be an efficient catalyst for acylation reaction of aldehydes with acetic anhydride in CH2Cl2.