41361-60-8

Upstream product

• 2033-89-8 3,4-dimethoxyphenol 
• 624-65-7 2-propynyl chloride 
• 106-96-7 propargyl bromide 

Downstream Products

• 522-17-8 cis-deguelin 
• 1044696-30-1 4-(3,4-dimethoxy-phenoxy)-1-(5-methoxy-2,2-dimethyl-7-nitro-2H-chromen-6-yl)-but-2-yn-1-one 
• 1044696-09-4 4-(3,4-dimethoxy-phenoxy)-1-(5-methoxy-2,2-dimethyl-8-nitro-2H-chromen-6-yl)-but-2-yn-1-one 
• 911056-98-9 1-adamantan-1-yl-4-(3,4-dimethoxy-phenoxymethyl)-1H-[1,2,3]triazole 
• 43015-67-4 4-(3,4-dimethoxyphenoxy)-1-(2-hydroxyphenyl)but-2-yn-1-one 
• 56484-59-4 1-(4-Benzyloxy-2-hydroxyphenyl)-4-(3',4'-dimethoxyphenoxy)-2-butyn-1-one 
• 343924-25-4 1-(2,4-dibenzyloxyphenyl)-4-(3,4-dimethoxyphenoxy)-2-butin-1-one 
• 343924-30-1 4-(2,4-dibenzyloxybenzoyl)-6,7-dimethoxychrom-3-ene 
• 56484-61-8 4-(4-benzyloxy-2-hydroxybenzoyl)-6,7-dimethoxychrom-3-ene 
• 909094-16-2 2-((R)-6,7-Dimethoxy-4-oxo-chroman-3-yloxy)-6-hydroxy-4-methoxy-benzaldehyde 
• 43015-66-3 2-[4-(3,4-Dimethoxy-phenoxy)-1-hydroxy-but-2-ynyl]-phenol 
• 616207-45-5 4-(3,4-dimethoxy-phenoxy)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)-but-2-yn-1-one 

Relevant academic research and scientific papers

Antitumor Potential of the Isoflavonoids (+)- And (-)-2,3,9-Trimethoxypterocarpan: Mechanism-of-Action Studies

Synthetically derived samples of (+)-(6aS,11aS)-2,3,9-trimethoxypterocarpan [(+)-1] and its enantiomer [(-)-1], both of which are examples of naturally occurring isoflavonoids, were evaluated, together with the corresponding racemate, as cytotoxic agents against the HL-60, HCT-116, OVCAR-8, and SF-295 tumor cell lines. As a result it was established that compound (+)-1 was particularly active with OVCAR-8 cells being the most sensitive and responding in a dose-dependent manner. A study of cell viability and drug-induced morphological changes revealed the compound causes cell death through a mechanism characteristic of apoptosis. Finally, a computational study of the interactions of compound (+)-1 and (S)-monastrol, an established, synthetically derived, potent, and cell-permeant inhibitor of mitosis, with the kinesin-type protein Eg5 revealed that both bind to this receptor in a similar manner. Significantly, compound (+)-1 binds with greater affinity, an effect attributed to the presence of the associated methoxy groups.

Synthesis of pterocarpans through palladium-catalyzed oxyarylation of alkoxy-2H-chromenes with o-iodophenols

The oxyarylation of alkoxy-2H-chromenes (1a-e) with o-iodophenols substituted by electron-withdrawing (CHO) and electron-donating (OMe) groups is studied under two experimental conditions: a) Pd(OAc)2, Ag2CO3 in PEG-400 at 140 °C, 10 min and b) oxime-based palladacycle, DIPEA, in PEG-400 at 150 °C, 3–4 h. Pterocarpans are obtained in moderate to good chemical yields.

NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a novel compound inhibiting Hsp 90 and to a pharmaceutical composition including same as an active ingredient. Compounds of formula 1 and formula 2 according to the present invention inhibit the accumulation of HIF-1α protein, which is an Hsp90 client protein, by suppressing Hsp90 expression, and effectively inhibit the activity of vascular endothelial growth factor (VEGF). Furthermore, said compounds have low cytotoxicity and can thus be used as an active ingredient for the treatment of diabetic retinopathy and arthritis.

NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a compound inhibiting Hsp90 and a pharmaceutical composition comprising the same as an active ingredient. The compounds represented by formula 1 and formula 2 of the present invention suppress the expression of Hsp90 so that they can inhibit the accumulation of HIF-1α, the Hsp90 client protein, and also efficiently inhibit the activation of VEGF. In addition, these compounds display low cytotoxicity, so that they can be effectively used as an active ingredient of an anti-cancer agent, a diabetic retinopathy treating agent, and an anti-arthritic agent.

Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action

A series of novel STAT3 inhibitors consisting of Michael acceptor has been identified through assays of the focused in-house library. In addition, their mode of action and structural feature responsible for the STAT3 inhibition were investigated. In parti

Microwave-assisted synthesis of 3,5-disubstituted isoxazoles and evaluation of their anti-ageing activity

One-pot uncatalysed microwave-assisted 1,3-dipolar cycloaddition reactions between in situ generated nitrile oxides and alkynes bearing protected antioxidant substituents, were regioselectively afforded 3,5-disubstituted isoxazoles. The yields were modera

Rhodium-catalyzed cyclopropanations of 2-aryl-2H-chromenes with dialkyl malonate esters. A comparison of α-diazo derivatives and phenyliodonium ylides

Rhodium-catalyzed reactions of 2-aryl-substituted 2H-chromenes with α-diazo esters prepared from dimethyl and tert-butyl methyl malonates were investigated, and the results were compared with reactions carried out with phenyliodonium ylides prepared from the same esters. The phenyliodonium ylide prepared from dimethyl malonate was found to give superior yields of cyclopropane products compared to the corresponding α-diazo equivalent. However, this result was reversed with tert-butyl methyl malonate when Rh 2(S-TBSP)4 was used to decompose the diazo compound. All reactions gave 1,1-cyclopropane diesters as single diastereomers.

Ph3PAuNTf2 as a superior catalyst for the selective synthesis of 2H-chromenes: Application to the concise synthesis of benzopyran natural products

Ph3PAuNTf2 (≈1 mol-%) catalyzes the selective cycloisomerization of substituted aryl propargyl ethers into 2H-chromenes in excellent yields. Benzofuran byproducts are formed only in the case of electron-deficient arenes, in up to 7% relative yield. The Ph 3PAuNTf2-catalyzed cyclization of aryl propargyl ethers was applied as a key step to the concise synthesis of the naturally occurring benzopyrans seselin, xanthyletin, precocenes I and II, 8-(3′,3′- dimethylallyl)wenteria chromene, and 2,2-dimethyl-8-prenylchromene-6-propenoic acid. Ph3PAuNTf2 is a general, highly efficient, and product-selective catalyst for the clean synthesis of 2H-chromenes from the cycloisomerization of aryl propargyl ethers.The Ph3PAuNTf 2-catalyzed cyclization was applied as a key step in the synthesis of several benzopyran-bearing naturally occurring substances. Copyright

SUBSTITUTED ALKYNYL PHENOXY COMPOUNDS AS NEW SYNERGISTS IN PESTICIDAL COMPOSITIONS

A composition comprising an alkynyl phenoxy compound of Formula (I) as a synergist and a pesticidal active ingredient is described, wherein R1 and R2, similar or different, are (C1-C4)alkyl or R1O- an

Substituted alkynyl phenoxy compounds and their uses

An alkynyl phenoxy compound of Formula (I) is described, wherein R1 and R2, similar or different, are (C1-C4)alkyl or R1O- and R2O- together represent a group -O-CH2-O-, -O-CH(CH