41371-53-3 Usage
Uses
Different sources of media describe the Uses of 41371-53-3 differently. You can refer to the following data:
1. (4S)-2-oxoimidazolidine-4-carboxylic Acid is an intermediate used in the synthesis of human BACE-1 inhibitors with cyclic urea structure. It is also used to prepare thiophene-3-carboxamides as kinase inhibitors.
2. Reactant for synthesis of human BACE-1 inhibitorsAdditive for crystal nucleation and growth
Check Digit Verification of cas no
The CAS Registry Mumber 41371-53-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,3,7 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 41371-53:
(7*4)+(6*1)+(5*3)+(4*7)+(3*1)+(2*5)+(1*3)=93
93 % 10 = 3
So 41371-53-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H6N2O3/c7-3(8)2-1-5-4(9)6-2/h2H,1H2,(H,7,8)(H2,5,6,9)/t2-/m0/s1
41371-53-3Relevant articles and documents
Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives
Park, Heuisul,Min, Kyeongsik,Kwak, Hyo-Shin,Koo, Ki Dong,Lim, Dongchul,Seo, Sang-Won,Choi, Jae-Ung,Platt, Bettina,Choi, Deog-Young
, p. 2900 - 2904 (2008/12/22)
We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modification of P3, P1, and P2′ and combination of SAR display a >100-fold increase in potency with good cellular activity (IC50 = 0.1
