41372-08-1

Basic information

• Product Name: alpha-Methyldopa sesquihydrate
• Synonyms: (-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate 99%;2-methyl-3-(3,4-Dihydroxyphenyl)-L-alanine sesquihydrate;BPBio1_000365;BSPBio_000331;C07194;IDI1_000142;KBio2_001417;KBio2_003985
• CAS NO: 41372-08-1
• Molecular Formula: C10H15NO5
• Molecular Weight: 229.23
• EINECS: 209-089-2
• Product Categories: Pharmaceutical intermediates;Amino Acids & Derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;L-Aromatic Amino Acid Decarboxylase
• Mol File: 41372-08-1.mol

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 441.6 °C at 760 mmHg
• Flash Point: 220.9 °C
• Appearance: /
• Vapor Pressure: 1.41E-08mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: Slightly soluble in water, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute mineral acids.
• Water Solubility: 0.1-1 g/100 mL at 23 ºC
• Sensitive: Air & Light Sensitive
• Stability: Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, coba
• Merck: 13,6080
• BRN: 2417244
• CAS DataBase Reference: alpha-Methyldopa sesquihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-Methyldopa sesquihydrate(41372-08-1)
• EPA Substance Registry System: alpha-Methyldopa sesquihydrate(41372-08-1)

Safety Data

• Statements: 20/21-36/37/38-42/43-65
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: YP2860000
• F: 10-23
• Hazardous Substances Data: 41372-08-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Antihypertensive agent

Uses

Potent inhibitor of invertase and glucosidase inhibitor with a different specificity of action to DNJ and castanospermine. Inhibits glucosidase I.

Uses

Antihypertensive agent.

Biological Activity

l-(-)-α-methyldopa (hydrate) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.

Purification Methods

Recrystallise methyldopa from H2O. [Reinhold et al. J Org Chem 33 1209 1968.] The L-isomer forms a sesquihydrate from H2O m 302-304o (dec), and the anhydrous crystals are hygroscopic,[] 23D -4.0o (c 1, 0.1N HCl), []546 +154.5o (c 5, CuSO4 solution). It has max at 281nm ( 2780). Its solubility in H2O at 25o is ~10mg/mL and the pH of an aqueous solution is ~5.0. It is insoluble in most organic solvents. [Stein et al. J Am Chem Soc 77 700 1955, Beilstein 4 IV 2505.]

InChI:InChI=1/2C10H13NO4.3H2O/c2*1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6;;;/h2*2-4,12-13H,5,11H2,1H3,(H,14,15);3*1H2/t2*10-;;;/m00.../s1

Upstream product

• 41372-02-5 BENZATHINE PENICILLINE G TETRAHYDRATE 
• 41371-53-3 2-IMIDAZOLIDONE-4-CARBOXYLIC ACID 
• 4137-12-6 1-(3-Nitrophenyl)-3-methylenepyrrolidine-2,5-dione 
• 4137-11-5 p,p',p''-(1-propanyl-3-ylidene)triphenol 
• 41371-14-6 CHOLESTEROL N-BUTYL CARBONATE 
• 4137-10-4 DIMCARB 
• 41370-57-4 (1S)-2β-Acetyloxy-4β-ethenyl-5α-(1-methylethenyl)-α,α,4-trimethylcyclohexanemethanol 
• 41370-56-3 Tricyclo[4.4.0.02,7]dec-8-ene-3-methanol, alpha.,alpha.,6,8-tetrmethyl-, stereoisomer 
• 41370-29-0 2-(3,3-dimethylcyclohexylidene)ethanol 
• 4137-02-4 3-(4-bromophenyl)-2-thioxo-1,3-thiazinan-4-one 
• 4136-97-4 METHYL 4-AMINOSALICYLATE 
• 4136-95-2 2,4,6-Trichlorobenzoyl chloride 
• 4136-91-8 TETRAISOPROPYLTHIURAM DISULFIDE 
• 4136-86-1 2-Butylsuccinic acid dimethyl ester 

Downstream Products

• 41372-10-5 PIPERAZINE CITRATE HYDRATE 
• 41372-20-7 R-(-)-Apomorphine 
• 41372-22-9 2-HYDROXYPROPANOIC ACID CALCIUM SALT, MONOHYDRATE 
• 41372-34-3 4-Amino-cis-2-Buten-1-ol 
• 41373-10-8 1-phenyl-1H-pyrazolo[4,3-c]pyridine 
• 41373-11-9 1-benzyl-1H-pyrazolo[4,3-c]pyridine 
• 41373-13-1 4H-Pyrazolo[4,3-c]pyridin-4-one,1,5-dihydro- 
• 4137-33-1 ethyl 1-thio-alpha-D-glucofuranoside 
• 41373-36-8 3-BENZOOXAZOL-2-YL-PHENYLAMINE 
• 41373-37-9 2-PHENYL-BENZOOXAZOL-5-YLAMINE 
• 41373-39-1 2-PiperidineMethanol, (2S)- 
• 4137-34-2 methyl 2,3,6-tri-O-benzoyl-4-O-(methylsulfonyl)hexopyranoside 
• 41373-82-4 3-iodo-1-[4-(3-iodopropanoyl)piperazin-1-yl]propan-1-one 
• 41373-90-4 4-PHENYL-3,6-PYRIDAZINEDIOL