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CAS

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41372-08-1

alpha-Methyldopa sesquihydrate, also known as α-Methyldopa sesquihydrate, is a white solid with potent inhibitory properties against invertase and glucosidase. It exhibits a unique specificity of action compared to DNJ and castanospermine, particularly inhibiting glucosidase I. alpha-Methyldopa sesquihydrate is recognized for its pharmaceutical applications, making it a valuable compound in the medical field.

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  • 41372-08-1 Structure

  • Basic information

    1. Product Name: alpha-Methyldopa sesquihydrate
    2. Synonyms: (-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate 99%;2-methyl-3-(3,4-Dihydroxyphenyl)-L-alanine sesquihydrate;BPBio1_000365;BSPBio_000331;C07194;IDI1_000142;KBio2_001417;KBio2_003985
    3. CAS NO:41372-08-1
    4. Molecular Formula: C10H15NO5
    5. Molecular Weight: 229.23
    6. EINECS: 209-089-2
    7. Product Categories: Pharmaceutical intermediates;Amino Acids & Derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;L-Aromatic Amino Acid Decarboxylase
    8. Mol File: 41372-08-1.mol

  • Chemical Properties

    1. Melting Point: >300 °C(lit.)
    2. Boiling Point: 441.6 °C at 760 mmHg
    3. Flash Point: 220.9 °C
    4. Appearance: /
    5. Density: N/A
    6. Vapor Pressure: 1.41E-08mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Refrigerator
    9. Solubility: Slightly soluble in water, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute mineral acids.
    10. Water Solubility: 0.1-1 g/100 mL at 23 ºC
    11. Sensitive: Air & Light Sensitive
    12. Stability: Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, coba
    13. Merck: 13,6080
    14. BRN: 2417244
    15. CAS DataBase Reference: alpha-Methyldopa sesquihydrate(CAS DataBase Reference)
    16. NIST Chemistry Reference: alpha-Methyldopa sesquihydrate(41372-08-1)
    17. EPA Substance Registry System: alpha-Methyldopa sesquihydrate(41372-08-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: 20/21-36/37/38-42/43-65
    3. Safety Statements: 24/25
    4. WGK Germany: 3
    5. RTECS: YP2860000
    6. F: 10-23
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 41372-08-1(Hazardous Substances Data)

41372-08-1 Usage

Uses

Used in Pharmaceutical Industry:
alpha-Methyldopa sesquihydrate is used as an antihypertensive agent for the treatment of hypertension. It helps regulate blood pressure by acting on the central nervous system, leading to a reduction in peripheral vascular resistance and overall blood pressure.
Used in Enzyme Inhibition Applications:
alpha-Methyldopa sesquihydrate is used as an enzyme inhibitor for inhibiting invertase and glucosidase, which are essential in various metabolic processes. Its unique specificity of action makes it a valuable compound for studying and targeting specific enzymatic pathways in the treatment of various diseases and conditions.

Biological Activity

l-(-)-α-methyldopa (hydrate) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.

Purification Methods

Recrystallise methyldopa from H2O. [Reinhold et al. J Org Chem 33 1209 1968.] The L-isomer forms a sesquihydrate from H2O m 302-304o (dec), and the anhydrous crystals are hygroscopic,[] 23D -4.0o (c 1, 0.1N HCl), []546 +154.5o (c 5, CuSO4 solution). It has max at 281nm ( 2780). Its solubility in H2O at 25o is ~10mg/mL and the pH of an aqueous solution is ~5.0. It is insoluble in most organic solvents. [Stein et al. J Am Chem Soc 77 700 1955, Beilstein 4 IV 2505.]

Check Digit Verification of cas no

The CAS Registry Mumber 41372-08-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,3,7 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 41372-08:
(7*4)+(6*1)+(5*3)+(4*7)+(3*2)+(2*0)+(1*8)=91
91 % 10 = 1
So 41372-08-1 is a valid CAS Registry Number.
InChI:InChI=1/2C10H13NO4.3H2O/c2*1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6;;;/h2*2-4,12-13H,5,11H2,1H3,(H,14,15);3*1H2/t2*10-;;;/m00.../s1

41372-08-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
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  • Alfa Aesar

  • (H56704)  (-)-3,4-Dihydroxy-alpha-methyl-L-phenylalanine sesquihydrate, 99%   

  • 41372-08-1

  • 1g

  • 124.0CNY

  • Detail

  • Alfa Aesar

  • (H56704)  (-)-3,4-Dihydroxy-alpha-methyl-L-phenylalanine sesquihydrate, 99%   

  • 41372-08-1

  • 5g

  • 435.0CNY

  • Detail

  • Sigma-Aldrich

  • (Y0001083)  Methyldopa for system suitability  European Pharmacopoeia (EP) Reference Standard

  • 41372-08-1

  • Y0001083

  • 1,880.19CNY

  • Detail

  • USP

  • (1426002)  Methyldopa  United States Pharmacopeia (USP) Reference Standard

  • 41372-08-1

  • 1426002-500MG

  • 4,662.45CNY

  • Detail

  • Aldrich

  • (857416)  (−)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alaninesesquihydrate  99%

  • 41372-08-1

  • 857416-5G

  • 596.70CNY

  • Detail

41372-08-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name L-α-Methyl DOPA Hydrate

1.2 Other means of identification

Product number -
Other names α-Methyldopa sesquihydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:41372-08-1 SDS

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