41373-39-1

Basic information

• Product Name: 2-PiperidineMethanol, (2S)-
• Synonyms: 2-PiperidineMethanol, (2S)-;(S)-Piperidin-2-ylMethanol;(2S)-2-PiperidineMethanol HCl
• CAS NO: 41373-39-1
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• Mol File: 41373-39-1.mol
• Article Data: 21

Chemical Properties

• Melting Point: 66-68 °C
• Boiling Point: 221.2°C at 760 mmHg
• Flash Point: 90.9°C
• Appearance: /
• Density: 0.951g/cm³
• Vapor Pressure: 0.0225mmHg at 25°C
• Refractive Index: 1.451
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 15.08±0.10(Predicted)
• CAS DataBase Reference: 2-PiperidineMethanol, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PiperidineMethanol, (2S)-(41373-39-1)
• EPA Substance Registry System: 2-PiperidineMethanol, (2S)-(41373-39-1)

Safety Data

• Hazardous Substances Data: 41373-39-1(Hazardous Substances Data)

Usage

General Description

"2-Piperidinemethanol, (2S)-" is a chemical compound with the molecular Formula C6H13NO. It belongs to the category of organic compounds known as piperidines, which are compounds containing a piperidine ring, a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms. The compound is also classified under the Piperidines subgroup. This chemical structure is composed of a six-membered ring with five carbon atoms and one nitrogen atom, contributing to its distinct chemical properties. Mainly used in the field of organic chemistry and pharmaceuticals, its chirality is towards the left due to the (2S)- configuration.

InChI:InChI=1/C6H13NO/c8-5-6-3-1-2-4-7-6/h6-8H,1-5H2/t6-/m0/s1

Upstream product

• 141-78-6 ethyl acetate 
• 3433-37-2 piperidin-2-ylmethanol 
• 87842-81-7 (6S)-1-aza-2,3-didehydro-8-oxabicyclo[4.3.0]nonan-9-one 
• 171561-66-3 (-)-(2R)-[(2S)-(hydroxymethyl)piperidin-1-yl]-2-phenylethanol 
• 212557-00-1 (S)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester 
• 28697-07-6 N-benzyloxycarbonyl D/L-pipecolinic acid 
• 28697-11-2 (S)-1-(carbobenzyloxy)-2-piperidinecarboxylic acid 
• 76700-85-1 6-Chlor-5-oxo-hexancarbonsaeuremethylester 
• 171561-64-1 (-)-(4R,9aS)-4-phenyltetrahydropyrido-[2,1-c][1,4]oxazin-3,6-dione 
• 171561-61-8 4-(6-oxo-5R-phenyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)butanoic acid methyl ester 
• 171561-59-4 (-)-5-oxo-6-[(R)-(phenyl)(phenylmethoxycarbonylamino)acetoxy]hexanoic acid methyl ester 
• 261963-32-0 (-)-4-[(3S,5R)-6-oxo-5-phenylmorpholin-3-yl]butanoic acid methyl ester 
• 3105-95-1 pipecolinic acid 
• 929917-69-1 (S)-(+)-piperidine-2-methanol hydrochloride 

Downstream Products

• 1191240-43-3 ((S)-1-(2-trifluoromethyl-phenylsulfonyl)piperidin-2-yl)methanol 
• 1072354-75-6 {(2S)-1-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]piperidin-2-yl}methanol 
• 353764-18-8 (S)-2-hydroxymethyl-1-(2-iodobenzoyl)piperidine 
• 1190970-39-8 2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-piperidin-2-yl]-methoxy]-1-[2-(piperidin-1-yl-methyl)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-5-yl]-ethanone 
• 1190970-43-4 2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-piperidin-2-yl]-methoxy]-1-[2-(pyrrolidin-1-yl-methyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-ethanone 
• 1072354-76-7 tert-butyl ({(2S)-1-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]piperidin-2-yl}methoxy)acetate 
• 1072354-77-8 ({(2S)-1-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]piperidin-2-yl}methoxy)acetic acid 

Relevant articles and documents

Protecting-Group-Directed Regio- and Stereoselective Oxymercuration-Demercuration: Synthesis of Piperidine Alkaloids Containing 1,2- and 1,3-Amino Alcohol Units

An efficient synthesis of naturally occurring 1,2- and 1,3-amino alcohol unit containing 2-substituted piperidine alkaloids and their analogues has been developed from l -pipecolinic acid. The protocol describes the regio- and stereoselective oxymercuration-demercuration of 2-alkenyl piperidines based on protecting groups to give piperidine alkaloids as a key step.

2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

The present invention relates to 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2- yl)picolinamide derivatives of formula (I) Formula (I) wherein Ar1, Q, and R1 to R5 are as described in the description, to their pre

Henry-Nef reaction: A practical and versatile chiral pool route to 2-substituted pyrrolidine and piperidine alkaloids

The paper describes the synergistic protocol developed by combinatorial Henry and Nef reaction for the synthesis of 2-substituted pyrrolidine and piperidine alkaloids containing 1,3-aminoketone and 1,3-amino alcohol units. The utility of the protocol is demonstrated by asymmetric synthesis of 12 natural products of which asymmetric synthesis of (-)-N-methylpelletierine is presented for the first time. The one-carbon homologation described also provides an alternate route for the synthesis of key intermediates homoprolinol and homopipecolinol used as synthetic precursors for several alkaloids and construction of β-amino acids from α-amino acids.