4138-19-6

Basic information

• Product Name: 6-tert-Butyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
• Synonyms: 6-tert-Butyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
• CAS NO: 4138-19-6
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.21508
• Mol File: 4138-19-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-tert-Butyl-2-oxo-1,2-dihydropyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-tert-Butyl-2-oxo-1,2-dihydropyridine-3-carbonitrile(4138-19-6)
• EPA Substance Registry System: 6-tert-Butyl-2-oxo-1,2-dihydropyridine-3-carbonitrile(4138-19-6)

Safety Data

• Hazardous Substances Data: 4138-19-6(Hazardous Substances Data)

Usage

General Description

6-tert-Butyl-2-oxo-1,2-dihydropyridine-3-carbonitrile is a chemical compound with the molecular formula C10H14N2O. It is a dihydropyridine derivative with a tert-butyl group attached to the nitrogen atom. 6-tert-Butyl-2-oxo-1,2-dihydropyridine-3-carbonitrile is commonly used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It has been studied for its potential therapeutic applications, including its role as a calcium channel blocker and its ability to act as a vasodilator. The chemical structure of 6-tert-Butyl-2-oxo-1,2-dihydropyridine-3-carbonitrile makes it a versatile intermediate in the development of various bioactive molecules, making it an important compound in the field of medicinal chemistry.

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 42731-37-3 sodium (1E)-4,4-dimethyl-3-oxopent-1-en-1-olate 
• 107-91-5 cyanoacetic acid amide 
• 109-94-4 formic acid ethyl ester 
• 130187-99-4 3-[1-Dimethylamino-meth-(Z)-ylidene]-5,5-dimethyl-2,4-dioxo-hexanoic acid methyl ester 
• 121017-77-4 ethyl 5-cyano-1,6-dihydro-2-tert-butyl-6-oxo-3-pyridine carboxylate 
• 116344-10-6 2-dimethylaminomethylene-4,4-dimethyl-3-oxo-pentanoic acid ethyl ester 
• 4370-12-1 1-cyanoformamide 
• 121017-83-2 2-tert-Butyl-5-cyano-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid 
• 144456-85-9 2-<5-cyano-1,6-dihydro-2-(1,1-dimethylethyl)-6-oxo-3-pyridyl>-2-oxoacetic acid 

Relevant articles and documents

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Synthesis and solid-state structures of alkyl-substituted 3-cyano-2-pyridones

A series of 3-cyano-pyridones carrying a variety of alkyl substituents at C-5 and C-6 has been synthesized and their solid-state structures have been studied. Hydrogen bonding interactions between individual pyridone molecules lead either to the formation of symmetric dimers of the R2 2(8) type or to helical chains of the C(4) type. Based on known and calculated structures for the 2-pyridone parent system, the solid-state structures can be divided in two groups representing cases with little external influence on the hydrogen bonding array (group A) and those with a larger external influence (group B).

Synthesis and cardiotonic activity of 2-substituted 5-cyano-1,6-dihydro-6-oxo-3-pyridinecarboxylic acids and their methyl or ethyl esters

The synthesis of ethyl or methyl esters of 5-cyano-1,6-dihydro-6-oxo-3-pyridinecarboxylic acids carrying as 2-substituent a polar group such as CO2C2H5, (CH2)2CO2CH3, (CH2)3CO2C2H5, CH2OCH3, or CF3 group is described. Also 2-[5-cyano-1,6-dihydro-2-(1,1-dimethylethyl)-6-oxo-3-pyridyl]-2-oxoace tic acid and 2,5,6,8-tetrahydro-2,5-dioxo-1H-thiopyrano[3,4-b]pyridine-3-carbonitri le were prepared. Nearly all the above esters gave routinely the corresponding carboxylic acids by alkaline hydrolysis followed by acidification. As milrinone analogues, the above compounds were tested on contractile activity and frequency rate of spontaneously beating atria from reserpine-treated guinea-pigs. 5-Cyano-2-trifuoromethyl-1,6-dihydro-6-oxo-3-pyridinecarboxylic acid and, in a lesser degree, the relative ethyl ester showed an appreciable positive inotropic activity, although inferior to that of milrinone.