41384-82-1

Usage

Class

Imidazole derivative

Structural features

Methyl group at the 2 position, nitro group at the 4 position, and phenyl group at the 1 position

Common uses

Synthesis of pharmaceuticals and agrochemicals, intermediate in the production of various drugs (antifungal agents, antiparasitic drugs, and anti-inflammatory medications)

Other potential applications

Corrosion inhibitor in metal protection, ligand in coordination chemistry.

Upstream product

• 19182-82-2 2-methyl-1,4-dinitro-1H-imidazole 
• 62-53-3 aniline 
• 696-23-1 2-methyl-4-nitro-1H-imidazole 
• 98-80-6 phenylboronic acid 
• 6293-66-9 diphenyliodonium p-toluenesulfonate 
• 696-23-1 2-methyl-5-nitro-1H-imidazole 

Downstream Products

• 158688-67-6 2-Methyl-1-phenyl-1H-imidazol-4-ylamine 

Relevant academic research and scientific papers

Practical copper-catalyzed N-arylation of amines with 20% aqueous solution of n-Bu4NOH

N-Arylation of a wide variety of amines with phenylboronic acid catalyzed by copper acetate under 20% aqueous solution of n-Bu4NOH was accomplished in good to excellent yields (up to 92%) and substrate conversions (up to 96%).

Regioselective N-arylation of nitroazoles. Determination of the structure of N-arylnitro-azoles on the basis of NMR spectroscopic data and quantum-chemical calculations

The N-arylation of a series of nitroazoles has been studied with the aid of diaryliodonium salts in the presence of CuI under the action of microwave radiation. It was found that alkylation proceeds regioselectively in each actual case with the formation

Synthesis and photochemical behaviour of 4-nitroimidazoles in the presence of oxygen

Synthesis and photochemical properties of 1-aryl-4-nitroimidazoles are described. These compounds are good sensitizers of superoxide ion. Only 1-phenyl-2-methyl-4-nitroimidazole is a photosensitizer of singlet oxygen.