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4-Hydroxy-3-(1-oxobutyl)-2H-1-benzopyran-2-one, also known as 4-hydroxybenzopyrone or taxifolin, is a naturally occurring chemical compound belonging to the flavonoid family. It is a yellow crystalline substance with a molecular formula of C15H12O5 and a molecular weight of 272.25 g/mol. 4-Hydroxy-3-(1-oxobutyl)-2H-1-benzopyran-2-one is found in various plants, including willow trees, and is known for its antioxidant, anti-inflammatory, and anticancer properties. It has been studied for its potential therapeutic applications in treating various diseases, such as cardiovascular disorders and neurodegenerative conditions. The chemical structure of 4-hydroxy-3-(1-oxobutyl)-2H-1-benzopyran-2-one consists of a benzopyran core with a hydroxyl group at the 4-position and a 1-oxobutyl group at the 3-position, which contributes to its biological activities.

4139-74-6

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4139-74-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4139-74-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,3 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4139-74:
(6*4)+(5*1)+(4*3)+(3*9)+(2*7)+(1*4)=86
86 % 10 = 6
So 4139-74-6 is a valid CAS Registry Number.

4139-74-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Butanoyl-4-hydroxycoumarin

1.2 Other means of identification

Product number -
Other names 3-butyryl-4-hydroxy-chromen-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4139-74-6 SDS

4139-74-6Relevant academic research and scientific papers

Synthesis and Evaluation of 4-Hydroxycoumarin Imines as Inhibitors of Class II Myosins

Brawley, Jhonnathan,Etter, Emily,Heredia, Dante,Intasiri, Amarawan,Nennecker, Kyle,Smith, Joshua,Welcome, Brandon M.,Brizendine, Richard K.,Gould, Thomas W.,Bell, Thomas W.,Cremo, Christine

, p. 11131 - 11148 (2020/11/09)

Inhibitors of muscle myosin ATPases are needed to treat conditions that could be improved by promoting muscle relaxation. The lead compound for this study ((3-(N-butylethanimidoyl)ethyl)-4-hydroxy-2H-chromen-2-one; BHC) was previously discovered to inhibit skeletal myosin II. BHC and 34 analogues were synthesized to explore structure-activity relationships. The properties of analogues, including solubility, stability, and toxicity, suggest that the BHC scaffold may be useful for developing therapeutics. Inhibition of actin-activated ATPase activity of fast skeletal and cardiac muscle myosin II, inhibition of skeletal muscle contractility ex vivo, and slowing of in vitro actin-sliding velocity were measured. Several analogues with aromatic side arms showed improved potency (half-maximal inhibitory concentration (IC50) 1 μM) and selectivity (≥12-fold) for skeletal myosin versus cardiac myosin compared to BHC. Several analogues blocked neurotransmission, suggesting that they are selective for nonmuscle myosin II over skeletal myosin. Competition and molecular docking studies suggest that BHC and blebbistatin bind to the same site on myosin.

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