41391-08-6Relevant academic research and scientific papers
Practical synthesis of urea derivatives from primary amines, carbon monoxide, sulfur, and oxygen under mild conditions
Mizuno, Takumi,Mihara, Masatoshi,Iwai, Toshiyuki,Ito, Takatoshi,Ishino, Yoshio
, p. 2825 - 2830 (2008/02/05)
A new and facile synthetic method for urea derivatives was developed under mild conditions, and contrasts with conventional preparation methods that need highly toxic reagents (phosgene) or severe reaction conditions. In our reaction system, N,N-dimethylformamide or dimethyl sulfoxide as solvent strongly accelerated the carbonylation of primary amines with sulfur under carbon monoxide (1 atm) at 20 °C to give the corresponding thiocarbamate salts. These salts were readily oxidized by molecular oxygen under similarly mild conditions to afford urea derivatives in good to excellent yields. This urea synthesis could also be applied to a new synthesis of aromatic ureas by use of 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethylformamide. Georg Thieme Verlag Stuttgart.
