41393-49-1

Upstream product

• 41394-71-2 2-(chloroacetylamino)propanedioic acid diethyl ester 
• 784-38-3 2-amino-5-chloro-2'-fluorobenzophenone 

Downstream Products

• 40408-69-3 1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-5-(chloromethyl)-1,2,4-triazole-3-carboxylic acid 
• 40408-66-0 8-chloro-6-(2-fluorophenyl)-4H-[1,2,4]triazolo[1,5-a][1,4]benzodiazepine-2-carboxylic acid 
• 50330-90-0 8-chloro-6-(2-fluorophenyl)-4H-<1,2,4>triazolo<1,5-a><1,4>benzodiazepine-2-carboxamide 

Relevant academic research and scientific papers

PERIPHERALLY RESTRICTED GABA POSITIVE ALLOSTERIC MODULATORS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME AND OTHER AILMENTS OF THE PERIPHERAL NERVOUS SYSTEM

The present invention provides compounds and compositions which are positive allosteric modulators of GABA-A receptors that selectively target the peripheral nervous system and organs of the body, and which do not pass through the blood-brain barrier. The compounds and compositions of the present invention are useful for treatment of diseases or disorders which are mediated by GABA-A neuronal activity, such as, for example, visceral pain, gut motility, irritable bowel syndrome, functional abdominal pain, functional idiopathic diarrhea, inflammatory bowel diseases, drug induced pain, bile salt malabsorption, lactase or other carbohydrate intolerance.

199. Azomalonic Ester Syntheses. Part I. One-Step Synthesis of Triazolobenzodiazepines from Azomalonates. Preparation of Novel Polyaza Tricycles from Diethyl (2-Chloroacetamido)malonate

A useful synthetic principle for the preparation of N-heterocycles consists in the base treatment of azomalonates carrying electrophilic centers in the side chain.Thus, pharmacologically active triazolobenzodiazepine-carboxamides can be prepared in o