41408-38-2Relevant articles and documents
STUDY ON THE BIOSYNTHESIS OF ECDYSONE PART IV: Synthesis of high specific activity -2,22-dideoxyecdysone Tissue distribution of the C-22 hydroxylase in Locusta migratoria
Haag, Thierry,Hetru, Charles,Kappler, Christine,Moustier, Anne Marie,Hoffmann, Jules A.,Luu, Bang
, p. 1397 - 1408 (2007/10/02)
We have synthesized a tritiated form of 2,22-dideoxyecdysone -3β,14α,25-trihydroxy-5β-cholest-7-en-6-one> of high specific activity (2.2 TBq/mmol).We have examined the capacity of various endocrine (prothoracic glands, follicle cells) and peripheral (fat body, Malpighian tubules) tissues of Locusta migratoria to use this molecule as a precursor of ecdysone biosynthesis.Efficient conversion of 2,22-dideoxyecdysone to 2-deoxyecdysone and to ecdysone could principally be monitored in the prothoracic glands and follicle cells.