41425-60-9

Usage

Uses

Used in Organic Synthesis:
2H-1,2,3-Triazole, 4-(bromomethyl)-2-phenylserves as a crucial intermediate in organic synthesis, facilitating the construction of complex molecular structures. Its unique reactivity and structural features make it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2H-1,2,3-Triazole, 4-(bromomethyl)-2-phenylis employed as a building block for the development of biologically active compounds. Its presence in molecular structures can contribute to enhanced pharmacological properties, such as improved binding affinity, selectivity, and bioavailability.
Used in Pharmaceutical Development:
2H-1,2,3-Triazole, 4-(bromomethyl)-2-phenylhas demonstrated antimicrobial, anticancer, and antifungal activities, making it an essential component in the development of new pharmaceuticals. Its diverse range of biological activities allows for its application in the treatment of various diseases and conditions.
Used in Antimicrobial Applications:
2H-1,2,3-Triazole, 4-(bromomethyl)-2-phenylis utilized as an antimicrobial agent, exhibiting activity against a broad spectrum of microorganisms. Its incorporation into pharmaceutical formulations can help combat bacterial, fungal, and other microbial infections.
Used in Anticancer Applications:
2H-1,2,3-Triazole, 4-(bromomethyl)-2-phenylalso shows promise as an anticancer agent, with potential applications in the development of novel therapeutics for the treatment of various types of cancer. Its ability to target and inhibit the growth of cancer cells makes it a valuable asset in oncology research and drug development.
Used in Antifungal Applications:
2H-1,2,3-Triazole, 4-(bromomethyl)-2-phenylis employed as an antifungal agent, effective against a range of fungal pathogens. Its use in antifungal medications can help treat and prevent fungal infections, contributing to improved patient outcomes.

Upstream product

• 3359-24-8 2-(2-phenyl-2H-1,2,3-triazole-4-yl)methanol 
• 3213-80-7 2-phenyl-1,2,3-triazole-4-carboxaldehyde 

Downstream Products

• 64404-12-2 (2-phenyl-2H-[1,2,3]triazol-4-yl)-acetonitrile 
• 1202941-93-2 (6S)-2-nitro-6-[(2-phenyl-2H-1,2,3-triazol-4-yl)methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains

Recently described biphenyl analogues of the antituberculosis drug PA-824 displayed improved potencies against M. tuberculosis but were poorly soluble. Heterobiaryl analogues of these, in which the first phenyl ring was replaced with various 5-membered ring heterocycles, were prepared with the aim of identifying potent new candidates with improved aqueous solubility. The compounds were constructed by coupling the chiral 2-nitroimidazooxazine alcohol with various halomethyl-substituted arylheterocycles, by cycloadditions to a propargyl ether derivative of this alcohol, or by Suzuki couplings on haloheterocyclic methyl ether derivatives. The arylheterocyclic compounds were all more hydrophilic than their corresponding biphenyl analogues, and several showed solubility improvements. 1-Methylpyrazole, 1,3-linked-pyrazole, 2,4-linked-triazole, and tetrazole analogues had 3- to 7-fold higher MIC potencies against replicating M. tb than predicted by their lipophilicities. Two pyrazole analogues were >10-fold more efficacious than the parent drug in a mouse model of acute M. tb infection, and one displayed a 2-fold higher solubility. 2009 American Chemical Society.

The stereoselective synthesis of nopinone based triazole ketones

The aldol reaction of nopinone 1 with triazole aldehydes followed by reduction with Zn/ZnCl2 furnished isomers 2a-d in satisfactory overall yields and excellent diastereoselectivities (ca 94% de).

Human β3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides

Compounds containing a 1,2,3-triazole-substituted benzenesulfonamide were prepared and found to be potent and selective human β3-adrenergic receptor agonists. The most interesting compound, trifluoromethylbenzyl analogue 12e (β3 ECs