4144-65-4Relevant academic research and scientific papers
Synthesis of N-substituted mono- and bi-heterocycles as antiinflammatory, anticonvulsant and anthelmintic agents
Shukla, Yogendra K.,Srivastava, Savitri D.
, p. 397 - 399 (2007/10/02)
Various N-substituted carbazoles (3a-f) and 1-methylpiperazines (4a-f) containing benzotriazole-, phenothiazine or diphenylaminoacetyl/propionyl moiety have been synthesized by appropriate methods.All the compounds have been screened for their antiinflammatory activity against the carrageenan-induced rat paw oedema in albino rats, anticonvulsant activity against pentylenetetrazole induced convulsions in mice and anthelmintic activity against the experimental infection of Ancyclostoma ceylanicum and Hymenolepsis nana in rats.Some of the compounds exhibit appreciable activity.
A simple, versatile synthetic route to N-1-aryl-, -heteroaryl-, -acylmethyl-, -carboxymethyl- and -alkyl-benzotriazoles via regiospecific or highly regioselective substitutions of benzotriazole
Katritzky,Wu
, p. 597 - 600 (2007/10/02)
In the absence of any added base in refluxing benzene or toluene, benzotriazole replaces the halogen atom of an α-halogenated ketone or a carboxylic ester to give the corresponding N-1-substituted benzotriazole as the only isomer. 2-Bromopyridine and 1-chloro-2,4-dinitrobenzene reacted similarly with benzotriazole to afford the corresponding N-1-substituted benzotriazole derivatives in quantitative yields. Alkyl halides reacted regioselectively to afford the N-1-alkylbenzotriazoles in ratios of more than 10 to 1 over the N-2 isomers. An α-(benzotriazol-1-yl)carboxylic ester was hydrolyzed into the corresponding carboxylic acid, which upon heating underwent smooth decarboxylation into the corresponding 1-alkylbenzotriazole.
