41443-48-5

Upstream product

• 104505-69-3 4-Methoxy-2-phenyl-1,5-benzothiazepin 
• 5855-57-2 4-phenyl-2-quinolinone 
• 74-88-4 methyl iodide 
• 85-99-4 2-acetamidobenzophenone 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 137-07-5 2-amino-benzenethiol 
• 637-44-5 phenylpropyolic acid 
• 5667-03-8 2-phenylbenzo[b][1,4]thiazepin-4(5H)-one 

Relevant academic research and scientific papers

Facile synthesis of 4-phenylquinolin-2(1H)-one derivatives from N-acyl-o-aminobenzophenones

An efficient synthesis of 4-phenylquinolin-2(1H)-one derivatives has been achieved in a one-pot reaction from N-acyl-o-aminobenzophenones 1a-c (a: acyl=acetyl; b: acyl=propanoyl; c: acyl=heptanoyl) using NaH as a base. Treatment of 1 with NaH provided the quinolones 2a-c with 62-83% yields, whereas the reaction in the presence of alkyl iodide (alkyl=methyl, ethyl, n-octyl) gave the corresponding N-alkylated quinolones 3a-g in 75-95% yields. The alkylation reaction of 4-phenylquinolin-2(1H)-one 2a with alkyl halide gave a mixture of N-alkylated and O-alkylated products. Comparison of IR and NMR data of the N-alkylated and O-alkylated compounds with those of 2a-c indicated that 2a-c exist as the lactam form.

Note on the Synthesis, Properties, and Reactions of 4-Methoxy-2-phenyl-1,5-benzothiazepine

The title compound 3 is synthesized by O-alkylation of the corresponding lactam 1.The behaviour of 3 is different from a compound with the same formula which has been published recently in this journal; the structure of 3 therefore was confirmed by X-ray