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6,8-dibromo-2-methyl-3-phenylquinazolin-4(3H)-one is a complex organic compound belonging to the quinazolinone class, characterized by a quinazoline core structure with a methyl group at the 2-position, a phenyl group at the 3-position, and two bromine atoms at the 6 and 8 positions. 6,8-dibroMo-2-Methyl-3-phenylquinazolin-4(3H)-one is known for its potential applications in medicinal chemistry, particularly as a precursor in the synthesis of various quinazolinone derivatives that exhibit biological activities, such as anticancer, anti-inflammatory, and antimicrobial properties. The presence of bromine atoms in the molecule can influence its reactivity and lipophilicity, which are important factors in drug design. The compound's structure and properties make it a subject of interest for further research and development in the field of pharmaceuticals and agrochemicals.

4145-21-5

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4145-21-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4145-21-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,4 and 5 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4145-21:
(6*4)+(5*1)+(4*4)+(3*5)+(2*2)+(1*1)=65
65 % 10 = 5
So 4145-21-5 is a valid CAS Registry Number.

4145-21-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 6,8-dibromo-2-methyl-3-phenylquinazolin-4-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:4145-21-5 SDS

4145-21-5Relevant academic research and scientific papers

FACTORS AFFECTING CYCLIZATION OF N-SUBSTITUTED 2-ACYLAMINO-3,5-DIBROMOBENZAMIDES TO 2,3-DISUBSTITUTED 6,8-DIBROMOQUINAZOLIN-4-ONES

Ismail, M. Fekry,Emara, Samir A.,Enayat, E. I.,Mustafa, Omina E. A.

, p. 1259 - 1263 (2007/10/02)

The factors affecting cyclization of N-substituted 2-acetylamino-3,5-dibromobenzamide (6a-c) to the corresponding 2,3-disubstituted 6,8-dibromoquinazolin-4-ones (7a-c) were studied.The cyclization process was found to depend on basicity and polarity of th

REACTIONS OF 6,8-DIBROMO-2-METHYL-3,1-BENZOXAZIN-4-ONE WITH SCHIFF BASES AND AZINES

Ismail, M. Fekry,El-Khamry, Abdel Momen A.,Abdel-Hamid, Hoda A.,Emara, Samir A.

, p. 35 - 40 (2007/10/02)

6,8-Dibromo-2-methyl-3,1-benzoxazin-4-one (1) reacts with benzylideneaniline or p-methoxybenzylideneaniline in dry benzene to give 2-acetylamino-3,5-dibromobenzanilide (2) in both cases.When the reaction was conducted in glacial acetic acid, 6,8-dibromo-2-methyl-3-phenylquinazolin-4-one (3) was obtained.The reaction of 1 with benzalazine in glacial acetic acid yielded a mixture of 3,5-dibromoanthranilic acid (6) and 3-benzylideneamino-6,8-dibromo-2-styrylquinazolin-4-on (7) while its reaction with p-methoxybenzylideneaniline under similar conditions gave a mixture of 2-acetylamino-N-p-methoxybenzylidineamino-3,5-dibromobenzhydrazide (8) and its cyclization product, 6,8-dibromo-3-p-methoxybenzylidineamino-2-methylquinazolin-4-one (9).When the reaction of 1 with the above azines were carried out in dry benzene, a mixture of 2-acetylamino-3,5-dibromobenzhydrazide (10) and 3,5-dibromoanthranilic acid was obtained in both cases.The structure in most cases were confirmed by comparision with authentic samples and by independent syntheses of 7 and 9 by the reaction of 10 with benzaldehyde and p-methoxybenzaldehyde, respectively.

Reactions with 3,1-Benzoxazin-4-ones. 3. Reactions of 6,8-Dibromo-2-methyl-3,1-benzoxazin-4-ones with Amines

Ismail, M. Fekry,Shams, Nabil A.,Salem, M. R.,Emara, S. A.

, p. 4172 - 4174 (2007/10/02)

We observed that the reactions of 6,8-dibromo-2-methyl-3,1-benzoxazin-4-one, 5, with primary amines occurs very slowly in ethanol solution at room temperature and that the product is usually the corresponding 2-acetamido-3,5-dibromobenzamide, 6.These resu

Reaction of 6,8-Dibromo-2-methyl-3,1-benzoxazin-4(H)-one with Some Nucleophilic Reagents : Synthesis of Quinazoline, Tetrazole and Benzimidazole Derivatives

Ismail, M. F.,Shams, N. A.,Naguib, M. I.

, p. 394 - 397 (2007/10/02)

6,8-Dibromo-2-methyl-3,1-benzoxazin-4(H)-one (1) reacts with primary amines, hydrazines, hydroxylamine and semicarbazide to give the ring opening products (2), (4), (9) and (12), respectively.Compounds (2) undergo cyclisation to 3-substituted 6,8-dibromo-2-methyl-4-quinazolones (3) when heated above their melting points.Action of selenium dioxide and N-bromosuccinimide on 3 has also been investigated.Compound (1) undergoes condensation with benzaldehyde to give (8) which reacts with benzylamine and hydrazine hydrate to give 9a and 9b, respectively.Compound (8) also reacts with hydrazoic acid to give a mixture of tetrazole (11) and benzimidazolone (12).

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