41452-28-2Relevant academic research and scientific papers
Competitive inhibitors of type B ribose 5-phosphate isomerases: design, synthesis and kinetic evaluation of new d-allose and d-allulose 6-phosphate derivatives
Mariano, Sandrine,Roos, Annette K.,Mowbray, Sherry L.,Salmon, Laurent
experimental part, p. 869 - 880 (2009/08/07)
This study reports syntheses of d-allose 6-phosphate (All6P), d-allulose (or d-psicose) 6-phosphate (Allu6P), and seven d-ribose 5-phosphate isomerase (Rpi) inhibitors. The inhibitors were designed as analogues of the 6-carbon high-energy intermediate pos
Anomerization of Furanose Sugars and Sugar Phosphates
Pierce, John,Serianni, Anthony S.,Barker, Robert
, p. 2448 - 2456 (2007/10/02)
Thermodynamic and kinetic parameters for the ring-opening and -closing reactions of several aldo- and ketofuanoses and their phosphate esters have been determined by NMR line-width and saturation-transfer methods.Cyclic forms interconvert via a single, acyclic carbonyl form under either acid or base catalysis.Ring-opening rates do not correlate with thermodynamic stability of the rings.For aldofuranose phosphates, α anomers open faster than β anomers; for ketofuranose phosphates the converse is observed.Intramolecular catalysis of anomerization by the phosphate group of sugar phosphates is documented.Biological and mechanistic implications of the observed kinetics are discussed.
