41465-21-8Relevant academic research and scientific papers
s-triazene based fluorous coupling reagent for direct amide synthesis
Mangawa, Shrawan Kumar,Bagh, Sangram Keshari,Sharma, Kumkum,Awasthi, Satish K.
supporting information, p. 1960 - 1963 (2015/03/18)
Abstract A new simple and efficient fluorous coupling reagent TriTFET (2,4,6-tris-(2,2,2-trifluoro-ethoxy)-[1,3,5] triazene) has been designed and synthesized for the direct amidation. The use of 5 mol % of TriTFET is good for the amide synthesis from carboxylic acids with amines in moderate to excellent yields (72-96%).
A convenient aminolysis of esters catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) under solvent-free conditions
Sabot, Cyrille,Kumar, Kanduluru Ananda,Meunier, Stéphane,Mioskowski, Charles
, p. 3863 - 3866 (2008/02/02)
Aminolysis of esters by using the organocatalyst 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) is reported. Secondary and tertiary amides were synthesized from alkyl or aryl esters with a variety of primary and secondary amines in good to excellent yields (60-94%) under solvent-free conditions (SFC).
Selective Monoacylation of Symmetrical Diamines via Prior Complexation with Boron
Zhang, Zhongxing,Yin, Zhiwei,Meanwell, Nicholas A.,Kadow, John F.,Wang, Tao
, p. 3399 - 3402 (2007/10/03)
(Equation presented) Pretreatment of a symmetrical primary or secondary diamine with 9-BBN prior to the addition of an acyl chloride significantly suppressed undesired diacylation, and the product of monoacylation predominated. The reactive preference is interpreted as the result of a selective deactivation of one nitrogen atom of the diamine by 9-BBN.
